Results 251 to 260 of about 53,473 (288)

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

iMeta, Volume 4, Issue 3, June 2025.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao, Huiyue Zhong, Yue He, Xiaojiao Li, Li Zhu, Zhanbo Xiong, Xiaoyin Zhang, Nan Zheng, Diego P. Morgavi, Jiaqi Wang   +9 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

A Preliminary Association Study of H19 Non‐Coding Gene Variants With Risk of Non‐Hodgkin Lymphoma: A Case–Control Study and Computational Analysis

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
Non‐Hodgkin lymphoma (NHL) is a kind of frequently occurring malignant tumor of the lymphoid hematopoietic system in the world. NHL comprises a large group of diverse lymphoid malignancies involving either the lymph nodes or extra nodal sites. It is more prevalent in males living in more developed countries over the age of 60 years.
Sara Kashani, Hoseinali Sasan, Behrouz Mollashahi, Gholamreza Bahari, Seyed Mahdi Hashemi, Mohsen Taheri   +5 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling and Simulation to Support a Change in the FDA‐Labeled Dosing Frequency of RHB‐105 Low‐Dose Rifabutin Triple Therapy for Helicobacter pylori Eradication

The Journal of Clinical Pharmacology, Volume 65, Issue 6, Page 779-786, June 2025.
Abstract Patient adherence is vital for Helicobacter pylori eradication. Simplifying therapy dosing schedules may promote patient adherence, enhance treatment success rates, and help mitigate the development of antibiotic resistance. We aimed to assess plasma and intragastric rifabutin, amoxicillin, and omeprazole concentrations comparing two dosing ...
Nimish Vakil, Colin W. Howden, Shailja C. Shah, Kuan‐Fu Chen, Elliot Offman, June S. Almenoff, Kely L. Sheldon   +6 more
wiley   +1 more source

Bacterial Extracellular Vesicles Exploit Filopodial Surfing and Retraction Mechanisms to Reach the Host Cell Body in an Actin‐Dependent Manner

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Extracellular vesicles derived from gram‐negative bacteria are nano‐sized particles of different size and origin released by these microbes and are collectively called bacterial extracellular vesicles (BEVs). These BEVs may serve as vehicles for delivering bacterial molecules to eukaryotic host cells.
Zia Ur Rehman, Ikenna Obi, Aftab Nadeem, Nicole Tegtmeyer, Steffen Backert, Anna Arnqvist   +5 more
wiley   +1 more source

Genetic Evidence of Association Between Gastroesophageal Reflux Disease and Hypertensive Disorders in Pregnancy

JGH Open, Volume 9, Issue 6, June 2025.
ABSTRACT Background The association between gastroesophageal reflux disease (GERD) and hypertensive disorders in pregnancy (HDP) is unclear. A bidirectional Mendelian randomization (MR) analysis was conducted to investigate the causal association between GERD and HDP using the public databases.
Qiong Li, Yajing Pang, Chaoyan Yue, Chenyang Zhao, Dongzhu Lei, Jin Zhou   +5 more
wiley   +1 more source

Hypocalcemia After Thyroidectomy in Patients Taking Proton Pump Inhibitors

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 3, June 2025.
Patients taking proton pump inhibitors may be more likely to experience of short‐term and permanent hypocalcemia after thyroid surgery. The current study is the largest to date, indicating an increased risk of hypocalcemia after thyroidectomy in patients taking proton pump inhibitors.
Maxwell Rossip, F. Jeffrey Lorenz, Neerav Goyal, David Goldenberg   +3 more
wiley   +1 more source

Bacterial Outer Membrane Vesicles: From Physics to Clinical

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao   +7 more
wiley   +1 more source

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Med Research, Volume 1, Issue 1, Page 32-61, June 2025.
Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin   +9 more
wiley   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, Volume 1, Issue 1, Page 62-102, June 2025.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source