Results 81 to 90 of about 5,152,662 (195)

Delphi consensus: First‐line use of biologics and small molecules in hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This Delphi Consensus study identified upgrade criteria for the use of biologics and small molecules as first‐line therapy in hidradenitis suppurativa (HS). European HS experts evaluated 16 clinical scenarios, voting on eligibility for therapy escalation.
Georgios Nikolakis, Erkan Alpsoy, Florian Anzengruber, Matthias Augustin, Falk G. Bechara, Pierre‐André Becherel, Farida Benhadou, Vincenzo Bettoli, Joana Cabete, Raffaele Dante Caposiena Caro, Antonella Di Cesare, Giovanni Damiani, Valentina Dini, Evangelos J. Giamarellos‐Bourboulis, Krisztián Gáspár, Katalin Glasenhardt, Philippe Guillem, Ariela Hafner, Barbara Horvath, John R. Ingram, Vaiva Jarienè, Gregor B. E. Jemec, Alexander Katoulis, Natalia Kirsten, Georgios Kokolakis, Piotr K. Krajewski, Aikaterini I. Liakou, Flavia Manzo Margiotta, Angelo V. Marzano, Antonio Martorell, Lukasz Matusiak, Dillon Mintoff, Alejandro Molina Leyva, Andreas Pinter, Anna Pirogova, Maurizio Podda, Francesca Prignano, Jorge Romani, Marco Romanelli, Elia Rosi, Samed Sahin, Ditte M. L. Saunte, Sylke Schneider‐Burrus, Mariano Suppa, Jacek Szepietowski, Andrea Szegedi, Simon Francis Thomsen, Thrasyvoulos Tzellos, Anastasia Trigoni, Hessel H. Van Der Zee, Kelsey Van Straalen, Skaidra Valiukevičiene, Eva Vilarrasa, Esther von Stebut, Christos C. Zouboulis   +54 more
wiley   +1 more source

Cherchez la femme: Power and Female Agency in Bactriaat the dawn of the Hellenistic Age

Karanos, 2020
Due prominently to the scanty nature of evidence on the ground attesting to an imperial presence which, however, historiographical sources claim to have been real and lasting over time, the satrapy of Bactria (roughly embracing northeastern Afghanistan ...
Marco Ferrario
doaj  

Bimekizumab efficacy using IHS4 outcomes in hidradenitis suppurativa: Results from BE HEARD I and II

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The majority of bimekizumab‐treated patients shifted from severe to mild and moderate IHS4 stages, and nearly 25% achieved an IHS4 of 0 by Week 48. Bimekizumab led to clinically meaningful improvements across IHS4 outcome measures. These data highlight an opportunity to address the need for effective treatments against draining tunnels.
Thrasyvoulos Tzellos, Evangelos J. Giamarellos‐Bourboulis, Kelsey R. van Straalen, Antonio Martorell, Brian Kirby, Afsaneh Alavi, Koremasa Hayama, Saakshi Khattri, Wayne Gulliver, Christopher J. Sayed, Leah Davis, Robert L. Rolleri, Christina Crater, Ingrid Pansar, Jérémy Lambert, Christos C. Zouboulis   +15 more
wiley   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Bioarchaeological and Palynological Studies of Graves from Samshvilde: Diachronic Case for Preliminary Reconstruction of Environment, Human Diet, Diseases and Remedies

Quaternary Environments and Humans
This paper presents the results of multidisciplinary research carried out at the Samshvilde Archaeological Complex (Georgia, South Caucasus) between 2016 and 2024 by a team from the University of Georgia, the Georgian National Museum, and Ivane ...
David Berikashvili, Nino Tavartkiladze, Levan Kvakhadze, Shota Tvaladze, Eliso Kvavadze   +4 more
doaj   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Updated S2k hidradenitis suppurativa (HS) guidelines provide expert consensus on diagnosis, assessment and comorbidities. Expanded substantially since the 2015 version, they reflect rapid growth in HS literature and aim to improve generalist‐level patient care through evidence‐informed, consensus‐based guidance.
G. B. E. Jemec, B. Villumsen, K. R. van Straalen, H. H. van der Zee, S. Valiukevičienė, T. Tzellos, J. C. Szepietowski, A. Szegedi, D. M. L. Saunte, M. Romanelli, H. Raynal, F. Prignano, E. P. Prens, M. Podda, A. Nassif, A. Molina‐Leyva, Ł. Matusiak, A. V. Marzano, B. M. McGrath, A. I. Liakou, B. Kirby, L. Kemény, E. Just, D. Ioannidis, J. R. Ingram, R. E. Hunger, B. Horváth, P. Guillem, Ø. Grimstad, E. J. Giamarellos‐Bourboulis, M. Dolenc‐Voljč, V. Del Marmol, Z. Bukvić Mokos, V. Bettoli, F. Benhadou, F. G. Bechara, C. C. Zouboulis   +36 more
wiley   +1 more source

Pathogenesis of hidradenitis suppurativa: From susceptibility to chronicity

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review describes hidradenitis suppurativa as a heterogeneous disorder in which genetic susceptibility, epithelial dysfunction, environmental exposures, immune activation and microbial ecology converge differently across patients and disease stages.
Kelsey R. van Straalen, Nisha S. Chandran, Jean M. Fletcher, Evangelos J. Giamarellos‐Bourboulis, Elia Rosi, Gregor B. E. Jemec   +5 more
wiley   +1 more source

Vicariance and dispersal in the Aegean Archipelago: Molecular phylogeography reveals the origin and divergence times of Hydropsyche (Trichoptera: Hydropsychidae) species

Journal of Systematics and Evolution, EarlyView.
Divergence times of Greek Hydropsyche lineages fall mostly within the Pliocene‐Pleistocene, rejecting ancient vicariance. Widespread species show shallow divergences consistent with dispersal, while island endemics exhibit deeper isolation patterns supporting a mixed vicariance‐dispersal model.
Anastasia Lampou, Paraskevi Niki Lampri, Cesc Múrria, Ioannis Karaouzas, Nikolaos Skoulikidis, Núria Bonada   +5 more
wiley   +1 more source

THE FATHERS, COMPUTERS AND US

Modern Theology, EarlyView.
Abstract This essay, designed as a complement to opinions expressed by Rowan Williams and some speakers at the conference in his honour, explores features of early Christianity which suggest a positive evaluation of artificial intelligence. Noting that the fear of reducing humans to machines has been joined in the modern age by the fear that machines ...
Mark J. Edwards
wiley   +1 more source

Theodor Steinbüchel's Great Figures of Christian Humanism

Modern Theology, EarlyView.
Abstract Theodor Steinbüchel (1888–1949) offers a study of eight figures in Western history who may be regarded as gestalts of Christian Humanism. He argued that none of these eight figures will ever return in the same way, but since there was an eternal conception of Christianity to which their ethos gave human form, each of these gestalts can be ...
Tracey Rowland
wiley   +1 more source