Results 31 to 40 of about 380,845 (294)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Factors for Perceived Helpfulness of Support Sources Among Survivors of Intimate Partner Violence

Behavioral Sciences
Intimate partner violence (IPV) has far-reaching health and social consequences, particularly for survivors experiencing polyvictimization—multiple forms of IPV such as physical, emotional, and sexual abuse. This study examined help-seeking behaviors and
Hyunkag Cho, Woojong Kim, Kaytee Gillis, Kasey Goetz   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Influence of Adult Attachment on COVID-19 Vaccination Intention: The Mediating Roles of Help-Seeking Style and Professional Help-Seeking Behavior

Vaccines, 2022
Vaccination against COVID-19 is regarded as one of the most promising interventions to control the pandemic. This study aimed to examine whether adult attachment affects an individual’s COVID-19 vaccination intention and whether this relationship is ...
Junyu Lu, Runzan Zhang, Xinping Zhang
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Help-seeking for Suicidal Thoughts in the Poisoned Patients at Loghman Hakim Teaching Hospital in Tehran, Iran

نشریه پرستاری ایران, 2020
Background & Aims: A history of suicide attempt is the most important risk factor for repeated and successful suicide. Seeking help is essential to access to proper mental healthcare services, and appropriate help-seeking could protect individuals ...
M Inanlou, SH Basiri, N Zamani, H Haghani   +3 more
doaj  

Teacher Help-Seeking Beliefs and Help-Seeking Networks [PDF]

, 2015
Teachers work within a network of teachers at their school whose members can be an important source of advice and help, yet they must seek help from their colleagues in order to benefit from this network. This study employs social network analysis to examine how help-seeking patterns among teachers are related to teachers’ curricular domain, years of ...
Makara Fuller, Kara, Karabenick, Stuart
openaire  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Doctoral Students' Help Seeking Behaviors

Journal of Effective Teaching in Higher Education
The qualitative data was collected from doctoral students on a weekly basis. Students were asked to complete a behavior log which consisted of 10 questions and inquired about their help-seeking and studying behaviors.
Deana Ford
doaj   +1 more source

Relationship between mental health literacy and professional psychological help-seeking attitudes in China: a chain mediation model

BMC Psychiatry, 2023
Background Mental health literacy is considered an important factor in promoting professional psychological help-seeking attitudes. However, it is important to clarify the emotional and behavioral factors that underlie this association.
Jingyuan Yang, Yunjia Li, Rui Gao, Hui Chen, Zhihui Yang   +4 more
doaj   +1 more source