Results 41 to 50 of about 380,845 (294)

Epistemic Cognitive Beliefs and Academic Help Seeking

open access: yesScientific Journal of King Faisal University: Humanities and Management Sciences, 2021
This study aims to identify the levels of Epistemic Cognitive Beliefs (ECB) and the behaviour of Academic Help Seeking (AHS) among secondary school students in Jordan and detect the ability of ECB to predict AHS behaviour.
Omar Atallah Al-Adamat
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

The role of social goal orientation and academic help-seeking behavior on mathematics achievement of primary students

open access: yesCogent Education
The purpose of this study was to examine the role of students' social goal orientation and academic help seeking behavior on their mathematics achievement. Data were collected from 930 Grade 8 primary school students in Ethiopia.
Fasika Teshale Wole   +2 more
doaj   +1 more source

Help Seeking Behaviour of Adolescents at Kolar

open access: yesJournal of Clinical and Biomedical Sciences, 2016
Background: Adolescents are full of energy, have significant drive and new ideas. They are a posi-tive force for the nation and are mostly responsible for its future productivity, provided they undergo over-all development in a healthy manner ...
Radha MS   +3 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Personality and help-seeking for psychological distress: a systematic review and meta-analysis

open access: yesFrontiers in Psychiatry
IntroductionThe effective management of depression, anxiety, and other forms of psychological distress depends on individuals’ readiness to seek and accept help for their mental suffering. Understanding which personality traits relate to help-seeking can
Anna Szücs   +12 more
doaj   +1 more source

Help Seeking Behaviors in Chronic Mental Diseases [PDF]

open access: yesPsikiyatride Güncel Yaklaşımlar, 2017
This study aims to investigate the studies conducted with the chronic psychiatric patients help seeking behavior in Turkey and determine the characteristics and reveal the current situation in this area. In order to determine the recent studies conducted
Kerime Bademli, Neslihan Lok
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

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