Results 151 to 160 of about 3,465,634 (408)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Recollected in tranquility : FE teachers’ perceptions of their initial teacher training [PDF]

open access: yes, 2003
"The main research question posed by the project was: ‘What are FE teachers’ perceptions of the effectiveness of initial training in helping them to teach and to support learning?’" -- page ...
Clow, Ros, Harkin, Joe, Hillier, Yvonne
core  

Cooperating to show that you care: costly helping as an honest signal of fitness interdependence

open access: hybrid, 2021
Pat Barclay   +3 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Early social-cognitive development as a dynamic developmental system—a lifeworld approach

open access: yesFrontiers in Psychology
Based on developmental systems and dynamic systems theories, we propose the lifeworld approach—a conceptual framework for research and a hypothesis concerning early social-cognitive development.
Joscha Kärtner, Moritz Köster
doaj   +1 more source

2007 Charter School Facility Finance Landscape [PDF]

open access: yes, 2007
Provides a roadmap for individual schools as they attempt to navigate the charter school facility landscape, and a policy guide for those interested in helping to rationalize the sector and develop more equitable funding for charter school ...
Clara Chae   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

First, Treat the System: The Atlantic Philanthropies' Effort to Promote Health and Equity in Viet Nam by Investing in a Healthier, More Equitable System of Policy, Practice, and Care [PDF]

open access: yes, 2012
Describes Atlantic's investments and early outcomes in helping develop a more complete and equitable primary care system as well as a culture of public health policy and practice in partnership with the East Meets West Foundation and local ...
Tony Proscio
core  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

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