Results 191 to 200 of about 3,465,634 (408)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Defender, Passive, and Pro-Bully: Exploring Bystanders' Intentions toward Cyberbullying. [PDF]

open access: yesPsychosoc Interv
Quintana-Orts C   +3 more
europepmc   +1 more source

Imitation and Cooperation in Different Helping Games [PDF]

open access: yes
The relation between imitation and cooperation in evolutionary settings presents complex aspects. From one hand, in any environment where egoists are favored over cooperators by selection processes, imitation should lead to a further spreading of the ...
Giangiacomo Bravo
core  

HELPING YOU KNOW WHAT YOU DON’T KNOW: A SELF-ASSESSMENT REVIEW OF PSYCHOTHERAPY IN CHILD AND ADOLESCENT PSYCHIATRY PRACTICE [PDF]

open access: bronze
Donald W. Bechtold   +4 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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