Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Girls' perceptions of their primary education and the possible role their mothers have had in helping to construct these perceptions. [PDF]
, 2002 Janet Anne Roberts
openalex
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cloudy Judgment: Helping Students Deeply Understand Cloud Formation
, 2011 Katie Borton, Hallie Satre, Jesse Wilcox
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A comparative study of the 30-item ProQOL 5, 12-item brief ProQOL-12, and 9-item short ProQOL scales in Slovak helping professionals. [PDF]
Sci RepDeriglazov D, Halamová J, Schroevers M.
europepmc +1 more source
Noticing and helping the neglected child:literature review [PDF]
, 2009 Daniel, Brigid +2 more
core +1 more source
https://doi.org/10.1186/s12889-018-5559-6When Helping Helps: Exploring Health Benefits of Cancer Survivors Participating in For-Cause Physical Activity Events
, 2018 Umstattd Meyer, Renée M. +3 more
openalex +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source