Results 201 to 210 of about 742,438 (343)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Helping Behaviour and Self-Esteem of the Helped in Inclusive Schooling: A Double-Edged Sword?

, 2018
Joseph Reginard Milinga, Mwajabu K. Possi   +1 more
openalex   +1 more source

Supporting Ukrainian refugees: Examining intergroup contact, empathy and European identity in promoting helping behaviours [PDF]

Calogero Lo Destro, Marika Rullo, Giovanni Telesca, Emilio Paolo Visintin   +3 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

How is parenting style related to child antisocial behaviour? : preliminary findings from the Helping children achieve study [PDF]

, 2012
Beckett, Celia, Cartwright, Sally, Doolan, Moira, Harry, Séan, Scott, Stephen   +4 more
core  

Sex-biased cooperation among immature peers: it matters who helps whom. [PDF]

Proc Biol Sci
Gupta A, Lindstedt C, Gerber N, Ritter R, Kokko H.   +4 more
europepmc   +1 more source

Sharing distress increases helping and contact intentions via social identification and inclusion of the other in the self: Children’s prosocial behaviour after an earthquake

, 2015
Loris Vezzali, John Drury, Annalisa Versari, Alessia Cadamuro   +3 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Task allocation in a cooperative breeder reflects current needs, not early-life experience. [PDF]

Sci Rep
Ferreira OV, Taborsky B.
europepmc   +1 more source

Prosocial Behaviour- A Major Determinant of Helping People in Health Emergency [PDF]

, 2016
P Sajithkumar, Ratna Prakash
openalex   +1 more source