Results 51 to 60 of about 59,591 (257)
Adult zebrafish as a model organism for behavioural genetics
BMC Neuroscience, 2010 Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie ...
Bally-Cuif Laure, Norton William
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Role of Emotions, Moral Disengagement and Gender in Supporting Victims of Bullying
Education Sciences, 2020 Previous research shows that classmates supporting victims’ defence is fundamental to combat bullying. To find a suitable response for the bullying problem, we must bear in mind how all the victim’s classmates respond and what variables can determine ...
Maria Carmen Cabrera +2 more
doaj +1 more source
Young military veterans show similar help seeking behaviour [PDF]
BMJ, 2007 A study undertaken by the King's Centre for Military Health Research had similar findings to those reported by Howerton et al.1 The study investigated the help seeking paths of young men (n=74) leaving Colchester Military Corrective Training Centre, colloquially known as the “military prison.” Young veterans found it difficult to access available ...
Lauren N, van Staden +5 more
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Adaptive behavioural syndromes due to strategic niche specialization
BMC Ecology, 2007 Background Behavioural syndromes, i.e. consistent individual differences in behaviours that are correlated across different functional contexts, are a challenge to evolutionary reasoning because individuals should adapt their behaviour to the ...
Bergmüller Ralph, Taborsky Michael
doaj +1 more source
Mental health help-seeking behaviours in young adults [PDF]
British Journal of General Practice, 2016 There is clinical and research consensus that significant cognitive, social, emotional development and adjustment to physical changes occurs during young adulthood, in the period between ages 18 and 24 years.1 While three–quarters of psychiatric disorders in adults emerge before the age of 25 years, a European study, comparing access to mental health ...
Mitchell, C.A., McMillan, B., Hagan, T.
openaire +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source