Results 161 to 170 of about 156,132 (258)

Impact of Red Blood Cell Deformability and Local Hematocrit on Microvascular Flow Resistance: Insights from In Vitro Microfluidic Measurements and Viscosity Modeling. [PDF]

Life (Basel)
Kaliviotis E, Stephanou P, Balabani S.
europepmc   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Frailty and Recovery Following Free Flap Reconstruction in Head and Neck Cancer: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To review the impact of frailty on various outcomes in geriatric head and neck cancer (HNC) patients undergoing microvascular free flap reconstruction (MFFR). Data Sources MEDLINE, Embase, and World of Science. Review Methods Following PRISMA guidelines, two independent reviewers performed a systematic review of MEDLINE, Embase, and ...
Anvitha R. Metpally, Mitchell T. Victor, Mirian Ramirez, Avinash Mantravadi, Michael W. Sim, Michael G. Moore, Jessica A. Yesensky, Janice L. Farlow   +7 more
wiley   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Relative hematocrit declines at the time of transfusion and postoperative outcomes after coronary artery bypass grafting: a retrospective cohort study. [PDF]

Braz J Anesthesiol
Sadr F, Jalali A, Vakili-Basir A, Pashang M, Barkhordari K.   +4 more
europepmc   +1 more source

The Diagnosis and Prenatal Management of Non‐RHD Alloimmunizations

Prenatal Diagnosis, EarlyView.
ABSTRACT Red blood cell (RBC) alloimmunization remains a relevant cause of hemolytic disease of the fetus and newborn (HDFN). Although RhD immunization has significantly decreased since the implementation of systematic prophylaxis, it is still the main cause of alloimmunization in pregnancy.
Mar Bennasar, Antoni Borrell
wiley   +1 more source

Fabrication of photoresist SU-8 pyrolyzed carbon electrodes and their integration in a microfluidic hematocrit detection system. [PDF]

Biomed Microdevices
Lee HY, Rogers JA, Kendrick C, Habibi S, Minerick AR.   +4 more
europepmc   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

SGLT2 inhibitors and secondary polycythemia: a systematic review and meta-analysis of hematologic effects in patients with type 2 diabetes. [PDF]

Eur J Clin Pharmacol
Ali EAH, Rabadi M, Aweer RA, Subahi E, Abdelmahmuod EA, Alshurafa A, Abdulgayoom M, Mudarres MF, Elshaikh U, Al-Mashdali A, Mohamed S.   +10 more
europepmc   +1 more source

Ganoderic Acids Alleviate Dexamethasone‐Induced Muscle Atrophy Potentially via Regulating Protein Synthesis/Degradation, Attenuating Oxidative Stress, and Antagonizing Glucocorticoid Receptor

Phytotherapy Research, EarlyView.
This work proposes a mechanism in which ganoderic acid A (GAA), the active monomer of ganoderic acids (GA) from Ganoderma lucidum, binds to the glucocorticoid receptor (GR) to form a GR‐GAA complex, thereby inhibiting DEX‐induced GR activation. This inhibition suppresses oxidative stress (ROS, MDA and 4‐HNE) by upregulating antioxidant proteins (Nrf2 ...
Kecheng Tang, Yan Yu, Yiru Chen, Zhizhen Huang, Hang Zhang, Yun Tian, Min Li, Yue Yin, Shaowei Li, Bingchuan Liu, Baoxue Yang   +10 more
wiley   +1 more source