Results 51 to 60 of about 149 (149)

Serological Indicators and Survival Analysis of Synaptophysin‐Positive Gastric Cancer Patients: A Retrospective Study

iLABMED, EarlyView.
SYN expression in patients with gastric cancer is correlated with the degree of differentiation and Lauren's typing. The prognosis of SYN‐positive gastric cancer patients is worse than that of SYN‐negative patients. ABSTRACT Background This study aims to determine prognostic indicators of synaptophysin (SYN) positive gastric cancer with neuroendocrine ...
Xuemei Wei, Xu Zhang, Jiaqi Zhang, Lin Zhu, Guanghong Guo   +4 more
wiley   +1 more source

Sex‐specific associations of Roseburia with uric acid metabolism and hyperuricemia risk in females

iMetaOmics, EarlyView.
Researchers recruited 623 participants, including 270 females, and used 16S rDNA sequencing to investigate gender differences in hyperuricemia. In healthy females, Roseburia was enriched, positively correlating with estrogen and negatively with uric acid, suggesting it is a potential biomarker affecting uric acid levels in females.
Zhihan Yang, Zeng Zhang, Mohan Chen, Jin Hu, Yingqi Qiu, Shijia Lin, Xiaolu Zhou, Jiachao Zhang, Shuaiming Jiang   +8 more
wiley   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, EarlyView.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source

Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gastrointestinal health is one of the fastest growing areas in the food and beverage industry, as its importance to overall health and well‐being is becoming increasingly recognized. Immunoglobulins play a key role in protecting the gastrointestinal tract, and nonbovine sources of immunoglobulins (including camel milk, which has a long history
Kirt R. Phipps, Sachin Patel, Kevin Scaife, Toby Holmes, Alica Šoltésová, Sandra Wingaard Thrane, Louise Kristine Vigsnæs, Nigel Baldwin, Christel Jørgensen   +8 more
wiley   +1 more source

Analysis of the experimental absorption spectrum of the rabbit lung and identification of its components

Journal of Biophotonics, EarlyView.
The broadband absorption coefficient spectrum of the rabbit lung was reconstructed from the absorption spectra of tissue components. The similar accumulation of melanin and lipofuscin was retrieved from the broadband baseline in the absorption coefficient spectrum, and the calculation of the absorption fold ratios for proteins, DNA and hemoglobin ...
Maria R. Pinheiro, Valery V. Tuchin, Luís M. Oliveira   +2 more
wiley   +1 more source

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, EarlyView.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source

Prevalence and Risk Factors for Augmented Renal Clearance in Neurocritical Ill Patients

Journal of Clinical Laboratory Analysis, EarlyView.
Augmented renal clearance is prevalent in critically neurological patients. Age is likely to significantly influence renal clearance in this population, especially patients with low Scr and cystatin C levels should be given more attention. ABSTRACT Background Augmented renal clearance (ARC) refers to a phenomenon in critically ill patients ...
Xiangru Ye, Qiang Yuan, Zhuoying Du, Haijun Yao, Lei Yang, Biwu Wu, Gang Wu, Weilin Shi, Yufeng Jin, Zhiping Liu, Caihua Xi, Jin Hu   +11 more
wiley   +1 more source

Reference Intervals of Hematological Parameters Among Healthy Adults in Northern Sudan: A Community‐Based Cross‐Sectional Study

Journal of Clinical Laboratory Analysis, EarlyView.
Two hundred fifty‐three adults were enrolled in a cross‐sectional study conducted in Northern Sudan. The RVs of hemoglobin 9.71–16.10 g/dL, red blood cells (RBC) 3.66–5.79 × 106/mm3, hematocrit (HCT) 28.02%–46.75%, mean corpuscular volume (MCV) 64.02–95.65 fL, mean corpuscular hemoglobin (MCH) 21.57–33.80 pg, mean corpuscular hemoglobin concentration ...
Mohamed F. Lutfi, Ahmed Ali Hassan, Ishag Adam   +2 more
wiley   +1 more source

Efanesoctocog Alfa Population Pharmacokinetics and Repeated Time‐To‐Event Analysis of Bleeds in Adults, Adolescents, and Children with Severe Hemophilia A

The Journal of Clinical Pharmacology, EarlyView.
Abstract Efanesoctocog alfa is a first‐in‐class high‐sustained factor VIII (HSF) replacement therapy for treatment of hemophilia A. This article presents population pharmacokinetics (PopPK) of efanesoctocog alfa and repeated time‐to‐event (RTTE) analysis of bleeding episodes in adults/adolescents (≥12 years of age) and children (<12 years).
Nancy Wong, Pratik Bhagunde, Joakim Nyberg, Suresh Katragadda, Marek Demissie, Annemieke Willemze, Craig Benson, Sreeraj Macha   +7 more
wiley   +1 more source

Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Magnitude of Drug–Drug Interaction Between Fezolinetant and CYP1A2 Inhibitors

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules, Yukio Otsuka, Jace C. Nielsen, Megumi Iwai, Peter L. Bonate   +4 more
wiley   +1 more source