Results 81 to 90 of about 149 (149)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Precision Dosing in Presence of Multiobjective Therapies by Integrating Reinforcement Learning and PK‐PD Models: Application to Givinostat Treatment of Polycythemia Vera

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Precision dosing aims to optimize and customize pharmacological treatment at the individual level. The integration of pharmacometric models with Reinforcement Learning (RL) algorithms is currently under investigation to support the personalization of adaptive dosing therapies.
Alessandro De Carlo, Elena Maria Tosca, Paolo Magni   +2 more
wiley   +1 more source

Precision Medicine in Oncology: Imatinib Dosing in the Obese Cancer Population Using Virtual Clinical Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT This study investigates the impact of obesity on imatinib pharmacokinetics in cancer patients by utilizing physiologically based pharmacokinetic modeling (PBPK) and virtual clinical trial approaches and evaluates the effectiveness of therapeutic drug monitoring (TDM)–guided dose adjustment to recover the imatinib trough concentration (Cmin ...
Khairulanwar Burhanuddin, Afzal Mohammed, Nurul Afiqah Burhanuddin, Raj K. S. Badhan   +3 more
wiley   +1 more source

Physiological alterations and predictors of death in neonatal calves with weak calf syndrome

Veterinary Record, EarlyView.
Abstract Background Weak calf syndrome (WCS) is characterised by weakness, poor vitality and difficulty standing or suckling. Early identification of physiological alterations and prognostic indicators is critical for improving the management and survival of weak calves.
Youngwoo Jung, Byoungsoo Kim, Ji‐Yeong Ku, Youngjun Kim, Kwang‐Man Park, Jonghun Baek, Mi‐Jin Lee, Jinho Park   +7 more
wiley   +1 more source

Insights on caesarean section in the southern tamandua (Tamandua tetradactyla)

Veterinary Record Case Reports, EarlyView.
Abstract An adult female southern tamandua (Tamandua tetradactyla) was rescued and taken to a veterinary centre for wildlife care. The patient's evaluation revealed an abnormal neurological status, along with prostration, diarrhoea, dehydration and bilateral corneal ulcers. Insecticide poisoning (carbamate, organophosphate or organochlorine) and canine
Diego Rodrigues Gomes, Gabriel Corrêa de Camargo, Zara Alves Lacerda, Eunice Oba, Fabiana Ferreira de Souza   +4 more
wiley   +1 more source

Extrahepatic biliary obstruction secondary to a peritoneopericardial diaphragmatic hernia in a dog

Veterinary Record Case Reports, EarlyView.
Abstract A 16‐month‐old, entire, male dobermann presented for evaluation of emesis, anorexia and lethargy. Upon examination, the dog was found to be severely icteric. Serum biochemistry revealed an elevated total bilirubin and alkaline phosphatase, and computed tomographic imaging revealed a peritoneopericardial diaphragmatic hernia with abdominal ...
Emily Durocher, Hilary Schwafel, Kimberly Cronin, Maureen Spinner   +3 more
wiley   +1 more source

Explosive Weapons Trauma Care Collective (EXTRACCT) Blast Injury Clinical Practice Guideline: Genito‐Urinary Trauma

World Journal of Surgery, EarlyView.
ABSTRACT Introduction This clinical practice guideline from the Explosive Weapons Trauma Care Collective (EXTRACCT) group provides a review of current best practice for the management of urogenital injury after blast injury due to unexploded ordinance and improvized explosive devices.
Timothy Craig Hardcastle, Cindy Ann Zietsman, Michael Mwandri, Jana B. A. Macleod, Adama Ouatarra, On behalf of the EXTRACCT Clinical Practice Guidelines Collaboration   +5 more
wiley   +1 more source

Haemosporidian parasites (Apicomplexa, Haemosporida) of breeding common starling Sturnus vulgaris in Latvia

Wildlife Biology, EarlyView.
Migratory behaviour in seasonal environments affects host–pathogen relationships, especially for vector‐transmitted blood parasites of the order Haemosporida. The common starling Sturnus vulgaris is a short‐distance migrant where the north‐eastern European breeding population spend the non‐breeding season in temperate mild western Europe.
Antonija Rimša, Raffaella Schmid, Aija Ilgaža, Martins Briedis, Oskars Keišs, Steffen Hahn   +5 more
wiley   +1 more source

Host species and age‐specific variation on Hepatozoon prevalence and its effect on body condition in two Neotropical crocodiles

Wildlife Biology, EarlyView.
Many populations of species belonging to the order Crocodilia are threatened due to illegal trafficking, indiscriminate hunting, and habitat loss and degradation affecting crocodilian health and parasitic load. Although several studies have revealed that crocodiles, caimans, and alligators are frequently infected by Hepatozoon spp., the results from ...
Alfonso Marzal, Wendy Flores‐Saavedra, Sergio Magallanes, Jaime Muriel, Jefferson Lezama‐Briceño, Luis Alberto García‐Ayachi, Esteban Fong, Carlos Mora‐Rubio, Carlos Mendoza, Blanca Saldaña, Alazne Díez‐Fernández, José Martin, Carlos Marcial Perea‐Sicchar, Manuel González‐Blázquez   +13 more
wiley   +1 more source

Intraoperative hematocrit and cardiopulmonary bypass [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2004
openaire   +2 more sources