Results 81 to 90 of about 156,132 (258)

Biomimetic Nanofiber Scaffold Coated With Acellular Matrices for Uterine Myometrial Tissue Engineering

Advanced NanoBiomed Research, EarlyView.
Schematic representation of acellular matrix generation from human uterine fibroblast cells, coating on polycaprolactone electrospun nanofibers, and subsequent in vitro and in vivo characterization. A tissue‐engineered scaffold tailored for uterine myometrium‐specific regeneration is designed. The electrospinning technique was used to fabricate aligned
Srividya Hanuman, Shripad S. Hebbar, Rishikesh Balvalli, Manasa Nune   +3 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Dynamics of blood indicators as a marker of the grain of the grease peritonitis

Journal of Education, Health and Sport, 2017
Introduction. Bile peritonitis is one of the most serious diseases of the abdominal cavity. The severity of its course and the percentage of mortality is primarily depends on endogenous intoxication.
I. V. Savytskyi, S. G. Znamerovskyi, O. L. Koshelnik, I. V. Miastkivska, P. E. Grigoriev, N. V. Yakimchuk   +5 more
doaj  

Aspects of testosterone replacement therapy in men with type 2 diabetes mellitus and testosterone deficiency

Mìžnarodnij Endokrinologìčnij Žurnal, 2019
Background. Testosterone deficiency is a medical condition that adversely affects male sexuality, reproduction, general health and quality of life. Testosterone therapy can improve the symptoms of testosterone deficiency and possibly stop the development
V.Ye. Luchytskyy, M.D. Tronko, Ye.V. Luchytskyy   +2 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Blood viscosity in tube flow: dependence on diameter and hematocrit

, 1992
Since the original publications by Martini et al. (Dtsch. Arch. Klin. Med. 169: 212–222, 1930) and Fahraeus and Lindqvist (Am. J. Physiol. 96: 562–568, 1931), it has been known that the relative apparent viscosity of blood in tube flow depends on tube ...
D. Neuhaus, A. R. Pries, P. Gaehtgens
core   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Changes in Ferritin and Hemoglobin Levels in Obese Patients before and after Bariatric Surgery: A Cohort Study

International Journal of Nutrition Sciences
Background: Bariatric surgery has been known as an efficient treatment for morbid obesity during the last few decades. Considering the high prevalence of anemia in obese patients and the changes in the iron status of the body after bariatric surgery, the
Paniz Zare, Zahra Sohrabi, Neda Haghighat, Morteza Zare, Najmeh Hejazi   +4 more
doaj   +1 more source

Hematocrit and clinical outcome in acute cerebral infarction.

, 1987
Hematocrits of 131 cerebral infarction cases were correlated with the outcome at 2 weeks. Bivariate analysis showed that cases with more intense admission deficit had lower admission hematocrit and that cases with poorer outcome had lower Day 2 and 4 ...
G Ozaita, F Bermejo, E Peinado, L Calandre, A Rodríguez-Antigüedad   +4 more
core   +1 more source

Model‐informed optimal dose selection of golcadomide in combination with R‐CHOP in patients with previously untreated aggressive B‐cell lymphoma

British Journal of Clinical Pharmacology, EarlyView.
Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng, Zhiling Yu, Mark Kaplan, Argyrios Gkasiamis, Akshay Sudhindra, Li Zhu, Manisha Lamba, Fan Wu   +7 more
wiley   +1 more source