Results 1 to 10 of about 10,662,454 (348)

Recent insights into the role of the microbiome in malignant and benign hematologic diseases.

Critical reviews in oncology/hematology, 2021
Growing evidence suggests the impact of microbiome alteration, named dysbiosis, on the development of neoplasms, infections, inflammatory diseases, and immuno-mediated disorders.
B. Fattizzo, F. Cavallaro, Francesco Folino, W. Barcellini   +3 more
semanticscholar   +1 more source

Which one is better for refractory/relapsed acute B-cell lymphoblastic leukemia: Single-target (CD19) or dual-target (tandem or sequential CD19/CD22) CAR T-cell therapy?

Blood Cancer Journal, 2023
CD19 chimeric antigen receptor (CAR) T-cell therapy has shown great success against B-cell acute lymphoblastic leukemia (B-ALL). Tandem and sequential CD19/CD22 dual-target CAR T-cell therapies have been developed to reduce the possibility of CD19 ...
Sining Liu, Xinyue Zhang, Haiping Dai, Wei Cui, Jia Yin, Zheng Li, Xiao Yang, Chunxiu Yang, Shengli Xue, Huiying Qiu, Miao Miao, Suning Chen, Zhengming Jin, Chengcheng Fu, Caixia Li, Aining Sun, Yue Han, Ying Wang, Lei Yu, Depei Wu, Qingya Cui, Xiaowen Tang   +21 more
doaj   +1 more source

CD7-directed CAR T-cell therapy: a potential immunotherapy strategy for relapsed/refractory acute myeloid leukemia

Experimental Hematology & Oncology, 2022
Relapsed/refractory acute myeloid leukemia (AML) patients generally have a dismal prognosis and the treatment remains challenging. Due to the expression of CD7 on 30% AML and not on normal myeloid and erythroid cells, CD7 is an attractive target for ...
Xuanqi Cao, Haiping Dai, Qingya Cui, Zheng Li, Wenhong Shen, Jinlan Pan, Hongjie Shen, Qinfen Ma, Mengyun Li, Sifan Chen, Juncheng Chen, Xiaming Zhu, Huimin Meng, Lin Yang, Depei Wu, Xiaowen Tang   +15 more
doaj   +1 more source

Clinical characteristics and prognostic significance of DNA methylation regulatory gene mutations in acute myeloid leukemia

Clinical Epigenetics, 2023
Background DNA methylation is a form of epigenetic modification that regulates gene expression. However, there are limited data on the comprehensive analysis of DNA methylation regulated gene mutations (DMRGM) in acute myeloid leukemia (AML) mainly ...
Xiaoyan Xu, Hong Wang, Haohao Han, Yifang Yao, Xueqian Li, Jiaqian Qi, Chengsen Cai, Meng Zhou, Yaqiong Tang, Tingting Pan, Ziyan Zhang, Jingyi Yang, Depei Wu, Yue Han   +13 more
doaj   +1 more source

Hematological Diseases and Osteoporosis [PDF]

International Journal of Molecular Sciences, 2020
Secondary osteoporosis is a common clinical problem faced by bone specialists, with a higher frequency in men than in women. One of several causes of secondary osteoporosis is hematological disease. There are numerous hematological diseases that can have a deleterious impact on bone health.
Gaudio A., Xourafa A., Rapisarda R., Zanoli L., Signorelli S. S., Castellino P.   +5 more
openaire   +2 more sources

Decitabine in combination with fludarabine and cyclophosphamide as a lymphodepletion regimen followed by CD19/CD22 bispecific targeted CAR T-cell therapy significantly improves survival in relapsed/refractory B-ALL patients

Experimental Hematology & Oncology, 2023
Relapse is a major limitation of chimeric antigen receptor (CAR) T-cell therapy. Here, we speculated that decitabine (DAC) in combination with fludarabine and cyclophosphamide (FC) as a lymphodepletion regimen may improve the efficacy of CD19/CD22 CAR T ...
Yunju Ma, Haiping Dai, Qingya Cui, Sining Liu, Liqing Kang, Xiaying Lian, Wei Cui, Jia Yin, Lingling Liu, Mengjie Cai, Lei Yu, Depei Wu, Xiaowen Tang   +12 more
doaj   +1 more source

A population-based study on myelodysplastic syndromes in the Lazio Region (Italy), medical miscoding and 11-year mortality follow-up. The Gruppo Romano-Laziale Mielodisplasie experience of retrospective multicentric registry [PDF]

, 2017
Data on Myelodysplastic Syndromes (MDS) are difficult to collect by cancer registries because of the lack of reporting and the use of different classifications of the disease.
Agabiti, Nera, Aloe Spiriti, Maria Antonietta, Andriani, Alessandro, Breccia, Massimo, Buccisano, Francesco, Cimino, Giuseppe, Criscuolo, Marianna, Davoli, Marina, De Fabritiis, Paolo, Faglioni, Laura, Fenu, Susanna, Fianchi, Luana, Gumenyuk, Svitlana, Latagliata, Roberto, Mancini, Stefano, Maurillo, Luca, Mayer, Flavia, Niscola, Pasquale, Nobile, Carolina, Piccioni, Anna Lina, Ricci, Roberto, Tafuri, Agostino, Tatarelli, Caterina, Trapã, Giulio, Voso, Maria Teresa, Zini, Gina   +25 more
core   +2 more sources

Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence. [PDF]

, 2016
Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope.
Stewart, Ethan R, Thompson, George R
core   +3 more sources

Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis: Current Status. [PDF]

, 2017
Purpose of reviewDiagnosis during early stages of invasive aspergillosis (IA) and targeted antifungal treatment has the potential to improve survival significantly.
Heldt, Sven, Hoenigl, Martin
core   +1 more source

Practical approach to monitoring and prevention of infectious complications associated with systemic corticosteroids, antimetabolites, cyclosporine, and cyclophosphamide in nonmalignant hematologic diseases.

Hematology. American Society of Hematology. Education Program, 2020
Corticosteroids constitute a first-line therapy for adults and children suffering from nonmalignant immune-mediated hematologic diseases. However, high disease relapse rates during the tapering period or upon drug discontinuation result in long-term ...
L. Malpica, S. Moll
semanticscholar   +1 more source