Results 141 to 150 of about 9,342,565 (376)

Porphyria cutanea tarda and hematological diseases [PDF]

, 1988
Gaetano De Rosa, Lucio Catalano, Carmine Selleri, M. Nigro, Andrea Camera, Bruno Rotoli   +5 more
openalex   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies [PDF]

, 1991
JH Antin, Barbara E. Bierer, B R Smith, James L.M. Ferrara, EC Guinan, Colin A. Sieff, DE Golan, RM Macklis, NJ Tarbell, Elizabeth Lynch   +9 more
openalex   +1 more source

Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers

Advanced Healthcare Materials, EarlyView.
The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao, Zheng Zhang, Xincai Wu, Yanwei Chen, Wenjun Li, Jiayan Bao, Xin Zhang, Baoding Chen   +7 more
wiley   +1 more source

The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute lymphoblastic leukemia

Cancer Medicine
Tyrosine kinase inhibitors (TKIs) have revolutionized Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL) treatment. The combination of blinatumomab and a TKI in the frontline setting has shown the safety and efficacy of the ...
Xiaoxia Wu, Shenqi Lu, Xinhui Zhang, Zhen Yang, Aining Sun, Depei Wu, Huifen Zhou, Miao Miao   +7 more
doaj   +1 more source

Use of recombinant human interleukin-2 in conjunction with syngeneic bone marrow transplantation in mice as a model for control of minimal residual disease in malignant hematologic disorders [PDF]

, 1991
Aliza Ackerstein, Eli Kedar, S Slavin
openalex   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Toward Noninvasively Imaging pH at the Surface of Implanted Orthopedic Devices in Live Rabbits Using X‐ray Excited Luminescence Chemical Imaging

Advanced Healthcare Materials, EarlyView.
Imaging pH in a live rabbit at the surface of a sensor‐coated titanium plate using X‐ray excited luminescent chemical imaging (XELCI). A raster scanning X‐ray beam generates radioluminescence from a spot on the sensor, and the luminescence passes through the tissue and is collected at two wavelengths to determine local pH.
Unaiza Uzair, Fenglin Wang, Donald Benza, Yash S. Raval, Sriparna Bhattacharya, Tzuen‐Rong J. Tzeng, Jeffrey N. Anker   +6 more
wiley   +1 more source

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse

BMC Medicine
Background Graft-versus-host disease (GVHD) and relapse are major complications following allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Xinghao Yu, Yiyin Chen, Lei Lei, Pengfei Li, Dandan Lin, Ying Shen, Chang Hou, Jia Chen, Yi Fan, Yi Jin, Huimin Lu, Depei Wu, Yang Xu   +12 more
doaj   +1 more source