Results 161 to 170 of about 9,376,530 (330)

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Clinical Studies of a Newly Developed Miconazole Preparation for Intravenous Drip Infusion (MJR-1761) in Hematologic Disease Patients with Deep-Seated Fungal Infection

, 1994
Hiroshi Kawada, Shuji Yonekura, Akira Masumoto, Yoshiaki Ogawa, Ryuki Fukuda, Tamotsu Sasao, Shigeki Watanabe, K Arimori, Hikaru FUJIWARA, Terumi Horiki, Hiroshi Sato, Yoshikatsu UMEDA, Yoshiaki Ohbayashi, Yukinobu Ichikawa, Tadami Nagao   +14 more
openalex   +2 more sources

Disseminated tuberculosis following reduced-intensity cord blood transplantation for adult patients with hematological diseases [PDF]

, 2004
Takashi Maeda, Eiji Kusumi, Masahiro Kami, Masateru Kawabata, Andre Le Pavoux, Sigeko Hara, Aki Chizuka, Naoko Murashige, Tetsuya Tanimoto, Tomoko Matsumura, Ko Yuji, Atsushi Wake, Shigesaburo Miyakoshi, S Morinaga, Shuichi Taniguchi   +14 more
openalex   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source

Isavuconazole Therapy for Patients with Hematologic Diseases and Hematopoietic Cell Transplantation with and Without Breakthrough Invasive Fungal Infections. [PDF]

J Fungi (Basel)
Herrera F, Torres D, Mendez G, Mañez N, Jordán R, Manzur A, Cabral M, Alderete M, García Allende N, Benso J, Salgueira C, Pereyra ML, Peretti H, Niveyro C, Castro M, Pollastrelli F, García Rojas S, Dapás J, Risso Patrón A, Fernández V, Gago R, Afeltra J, Multicenter study on Isavuconazole for Treatment and Prophylaxis of Invasive Fungal Infections in Patients with Hematologic Malignancies and Hematopoietic Cell Transplantation (EMISA).   +22 more
europepmc   +1 more source

Successful Engraftment After Reduced-Intensity Umbilical Cord Blood Transplantation for Adult Patients with Advanced Hematological Diseases [PDF]

, 2004
Shigesaburo Miyakoshi, Koichiro Yuji, Masahiro Kami, Eiji Kusumi, Yukiko Kishi, Kazuhiko Kobayashi, Naoko Murashige, Tamae Hamaki, Sung‐Won Kim, Junichi Ueyama, Shinichiro Mori, Shinichi Morinaga, Yoshitomo Muto, S Masuo, Mineo Kanemaru, Tatsuyuki Hayashi, Yoichi Takaue, Shuichi Taniguchi   +17 more
openalex   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Epidemiology and Characteristics of Invasive Yeast Infections in Patients with Hematologic Diseases: 12-Year Single-Center Retrospective Cohort Study. [PDF]

J Fungi (Basel)
Kim DY, Oh K, Song M, Kweon H, Nho D, Hong H, Lee R, Lee DG, Cho SY.   +8 more
europepmc   +1 more source

Comparison of humoral and cellular immune responses in hematologic diseases following completed vaccination protocol with BBIBP-CorV, or AZD1222, or BNT162b2 vaccines against SARS-CoV-2. [PDF]

Front Med (Lausanne), 2023
Szabó E, Modok S, Rónaszéki B, Faragó A, Gémes N, Nagy LI, Hackler L, Farkas K, Neuperger P, Balog JÁ, Balog A, Puskás LG, Szebeni GJ.   +12 more
europepmc   +1 more source