Results 251 to 260 of about 9,342,565 (376)

A Complementarity‐Based Approach to De Novo Binder Design

Advanced Science, EarlyView.
A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko, Valeriia Hatskovska, Murray Coles, Narges Aghaallaei, Natalia Pashkovskaia, Natalia Borbarán‐Bravo, Matteo Pilz, Philip Bucher, Mareike Volz, Joana Pereira, Marcus D. Hartmann, Ghazaleh Tabatabai, Judith Feucht, Stefan Liebau, Patrick Müller, Andrei N. Lupas, Julia Skokowa, Mohammad ElGamacy   +17 more
wiley   +1 more source

Clinical outcomes of patients with lymphoid blastic phase of chronic myeloid leukemia treated with CAR T-cell therapy

Blood Cancer Journal
Yujie Liu, Yuqing Tu, Jinyan Xiao, Yifan Shen, Biqi Zhou, Qiannan Yang, Lei Yu, Lijuan Qi, Jia Chen, Tianhui Liu, Depei Wu, Yang Xu   +11 more
doaj   +1 more source

Obinutuzumab in Combination with Alternative Chlorambucil Schedules in Front-Line Treatment of Chronic Lymphocytic Leukemia: A Study by KroHem, the Croatian Cooperative Group for Hematologic Diseases. [PDF]

Biomedicines
Aurer I, Jakšić O, Bašić-Kinda S, Mišura-Jakobac K, Sinčić-Petričević J, Novaković-Coha S, Galušić D, Holik H, Valković T, Županić-Krmek D, Hude-Dragičević I, Milunović V, Pejša V.   +12 more
europepmc   +1 more source

INCREASE IN THE NUMBER OF PATIENTS WITH HEMATOLOGICAL DISEASE RECEIVING LONG-TERM PLATELET TRANSFUSION AT AN OUTPATIENT CLINIC

, 2003
Chikara Sakai, Akihiro Ishii, Michi Sato, Michiko Ito, Yutaka Inada   +4 more
openalex   +2 more sources

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Editorial: Practical recommendations and consensus for the management of immune mediated hematologic diseases. [PDF]

Front Immunol
Fattizzo B, Berentsen S, Barcellini W.
europepmc   +1 more source

ORL@Cu‐MOF Boost Cuproptosis and Suppress Fatty Acid Metabolism for Cancer Lymph Node Metastasis Synergistic Therapy

Advanced Science, EarlyView.
The fabrication of ORL@Cu‐MOF and the mechanism of synergistic therapy by cuproptosis, reprogram fatty acid metabolism and anti‐PD‐1. Abstract Lymph node metastasis (LNM) is one of the significant characteristics of poor prognosis in oral squamous cell carcinoma (OSCC), strongly associated with high mortality rates.
Zi‐Zhan Li, Yi Liu, Kan Zhou, Lei‐Ming Cao, Guang‐Rui Wang, Jinmei Wu, Yi‐Fu Yu, Yao Xiao, Bing Liu, Qiuji Wu, Zhiyong Song, Lin‐Lin Bu   +11 more
wiley   +1 more source

Adult AML with NUP98 rearrangements should be stratified into adverse-risk group

Blood Cancer Journal
Wusixian Huang, Man Wang, Jundan Xie, Qian Wang, Haiping Dai, Suning Chen, Qinrong Wang   +6 more
doaj   +1 more source

Base Editors-Mediated Gene Therapy in Hematopoietic Stem Cells for Hematologic Diseases. [PDF]

Stem Cell Rev Rep
Zhang C, Xu J, Wu Y, Xu C, Xu P.
europepmc   +1 more source

Management and Clinical Outcome of Posterior Reversible Encephalopathy Syndrome in Pediatric Oncologic/Hematologic Diseases: A PRES Subgroup Analysis With a Large Sample Size. [PDF]

Front Pediatr, 2021
Hun M, Xie M, She Z, Abdirahman AS, Li C, Wu F, Luo S, Han P, Phorn R, Wu P, Luo H, Chen K, Tian J, Wan W, Wen C.   +14 more
europepmc   +1 more source