Results 151 to 160 of about 407,671 (265)
Assessment of Transitioning from High-Potency to Low-Potency Inhibitors in Chronic Myeloid Leukemia (CML) Patients: The Downgrading-Impact (D-IMPACT) Project. [PDF]
Cancers (Basel)Abruzzese E, Crugnola M, Garuffo L, Markovic U, Trawinska MM, Barulli S, Maggi A, Galimberti S, Cattaneo D, Sannipoli D, D'Adda M, Chiara E, Bonifacio M, Russo Rossi AV, Beltrami G, Russo S, Crisà E, Sanpaolo G, Cavazzini F, Loglisci G, Fava C, Giai V, Scortechini AR, Scappini B, Dalmazzo M, Binotto G, Bocchia M, Facchinelli D, Di Veroli A, Pascale SP, Leporace A, Bernardi S. +31 moreeuropepmc +1 more sourceLarge‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens
Advanced Science, EarlyView.Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang +7 morewiley +1 more sourceOccult hepatitis B virus infection status is not associated with impaired efficacy of anti-CD19 CAR-T-cell therapy for lymphoma and shows a distinct immune toxicity profile: Results from the CART-SIE study. [PDF]
HemaspherePolverelli N, Chiappella A, Carniti C, Zinzani P, Musso M, Tisi MC, Ciceri F, Cutini I, Santoro A, Chiusolo P, Barbui AM, Farina M, Donzelli L, Brunello L, Martino M, Krampera M, Castellino A, Grillo G, Botto B, Olivieri J, Clerico M, Musto P, Olivieri A, Bianchessi A, Defrancesco I, Losi G, Zerbi C, Martini G, Roncoroni E, Gotti M, Benevento MG, Taurino A, Fedina A, Corradini P, Arcaini L. +34 moreeuropepmc +1 more sourceHarnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma
Advanced Science, EarlyView.MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu +21 morewiley +1 more sourceValidation of ELN 2024 genetic classification in patients with AML treated with HMA-based regimens: PETHEMA registry study. [PDF]
Blood NeoplasiaBarragán E, Gil JV, Ayala R, Chillón C, Soria E, Bilbao C, Larráyoz MJ, Prados de la Torre E, Solana A, Martínez-Cuadrón D, Rodríguez-Veiga R, Rodríguez-Arbolí E, Tormo M, Martínez P, Lavilla E, García-Garay MC, Arce O, Bergua J, Serrano J, Botella C, Lacalzada C, Almela-Gallego A, Lopez-Lorenzo JL, Valero M, Ibañez F, Foncillas MÁ, Rodriguez-Medina C, Olave M, Gómez-Correcha KG, Calderón MT, Bernal T, Labrador J, Oliva A, Madrigal MD, Hermosín L, Amador L, García-Belmonte D, Herrera P, Vives S, Perez-Encinas M, Algarra L, Casado S, Martínez-Chamorro C, Polo M, Balerdi A, Roldán A, Couto C, Pereiro M, Vanegas R, Llop M, Sargas C, Cionfrini A, Mendizábal Y, Sánchez J, Calasanz MJ, Gómez-Casares MT, Pérez-Simón JA, García-Sanz R, Martínez-López J, Montesinos P, PETHEMA group. +60 moreeuropepmc +1 more sourceTME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy
Advanced Science, EarlyView.A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song +17 morewiley +1 more sourceComparison of Early Response to Selumetinib Therapy in Adolescents and Children With NF1-related Plexiform Neurofibromas. [PDF]
In VivoStyczyńska J, Marjańska A, Jatczak-Gaca A, Karwacki M, Walenciak J, Garus K, Bilska K, Mizia-Malarz A, Badowska W, Sławińska D, Węcławek-Tompol J, Chaber R, Bień E, Jezierska M, Karolczyk G, Skalska-Sadowska J, Styczyński J. +16 moreeuropepmc +1 more sourceMicroglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy
Advanced Science, EarlyView.Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei +15 morewiley +1 more sourceCross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES
Advanced Science, EarlyView.In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai +5 morewiley +1 more sourceOutpatient Rescue With Stem Cells Boost for Refractory Hematotoxicity Following anti-BCMA CAR T-Cell Therapy: A Case Report. [PDF]
Case Rep HematolLoukhnati M, Hebraud B, Cazaux M, Borel C, Bories P, Martignoles JA, Granell M, Cougoul P, Dion J, Oberic L, Huynh A, Tazi I, Perrot A. +12 moreeuropepmc +1 more source
