Results 281 to 290 of about 575,997 (353)

GDF15 Ameliorates Deoxynivalenol‐Induced Anemia by Resolving Ribosomal Stress–Mediated Erythropoietic Arrest

Advanced Science, EarlyView.
Deoxynivalenol induces anemia by disrupting hematopoietic homeostasis and impairing erythroid lineage commitment and differentiation via ribosomal stress–mediated G1/S cell cycle arrest. GDF15 supplementation alleviates this arrest through the β‐catenin–Myc–p21 signaling axis, highlighting GDF15 as a potential therapeutic target for DON‐induced ...
Yan Li, Peijun Jia, Jingxin Zhang, Huan Zhang, Bing Li, Jiawei Chang, Yating Li, Longzhen Zhao, Yazhe Zhen, Tingting Zheng, Yuanlin Xu, Xiuli An, Shijie Zhang   +12 more
wiley   +1 more source

Revised "iRR6" model in intermediate-1 risk myelofibrosis patients treated with ruxolitinib. [PDF]

Cancer
Palandri F, Branzanti F, Bonifacio M, Elli EM, Morsia E, Farina M, Tiribelli M, Benevolo G, Beggiato E, Martino B, Caocci G, Pugliese N, Tieghi A, Crugnola M, Binotto G, Cavazzini F, Abruzzese E, Isidori A, Dedola A, Scalzulli E, Duminuco A, Tosoni L, Strazimiri A, Lemoli RM, Cilloni D, Bocchia M, Pane F, Sartor C, Heidel FH, Breccia M, Palumbo GA, Kuykendall AT.   +31 more
europepmc   +1 more source

Hyaluronic Acid Hydrogel Implants for Sustained Release of Oxaliplatin and Resiquimod to Prevent Hepatocellular Carcinoma Recurrence Post‐Radiofrequency Ablation

Advanced Science, EarlyView.
Preparation of a biopolymer‐based immune implant (BI) for the sustained release of R848 and oxaliplatin (OXA), enabling immune activation and preventing recurrence after radiofrequency ablation (RFA) treatment in hepatocellular carcinoma (HCC). Abstract Hepatocellular carcinoma (HCC) remains a global challenge due to limited therapies and high ...
Yuezhan Shan, Hongyu Chu, Sheyu Ye, Guofeng Ji, Jiayi Zhao, Xinghui Si, Yumin Zhong, Youmao Tao, Jingwei Shi, Xuedong Fang   +9 more
wiley   +1 more source

A plain language summary of the CEPHEUS study of daratumumab plus bortezomib, lenalidomide, and dexamethasone for people with newly diagnosed multiple myeloma who are not expected to receive a stem cell transplant. [PDF]

Future Oncol
Usmani SZ, Facon T, Hungria V, Bahlis NJ, Venner CP, Braunstein M, Pour L, Martí JM, Basu S, Cohen YC, Matsumoto M, Suzuki K, Hulin C, Grosicki S, Legiec W, Beksac M, Maiolino A, Takamatsu H, Perrot A, Turgut M, Ahmadi T, Liu W, Wang J, Chastain K, Vermeulen J, Krevvata M, Lopez-Masi L, Carey J, Rowe M, Carson R, Zweegman S.   +30 more
europepmc   +1 more source

Faecalibaculum rodentium Alleviates Ionizing Radiation‐Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate

Advanced Science, EarlyView.
The model shows the probiotics screening and underlying mechanisms of F. rodentiumn in alleviating IR‐induced tissue injury. Stress‐induced STAT3 mitochondria localization decreases F. rodentium abundance and butyrate concentration. Supplementation of F.
Hanyong Zhu, Hui Guo, Na Sun, Rui Xiao, Binbin Ji, Ruihan Jiang, Fuxing Dong, Chen Yao, Xuerong Wang, Rongqing Li, Jie Zhao, Xueqin Li, Shengzhe Gong, Yongqin Qin, Xin Chen, Yuchen Pan, Takayuki Ikezoe, Jing Yang   +17 more
wiley   +1 more source

Assessing drivers of disparate outcomes and applicability of risk stratification in a cohort of patients with myelofibrosis. [PDF]

Blood Cancer J
Palmer A, Rauscher G, Schoen A, Burkart M, Dunton A, Au C, Dave A, Nassar A, Zhu S, O'Hara A, Africawala N, Erra A, Solipuram V, Abraham I, Tsai SB, Zia M, Larson ML, Rondelli D, Altman JK, Stock W, Khan I, Odenike O, Patel AA.   +22 more
europepmc   +1 more source

Intravenous iRGD‐Guided, RBC‐Membrane Camouflaged Lactococcus Lactis Remodels Cold NSCLC and Enhances PD‐1 Blockade

Advanced Science, EarlyView.
This study presents an engineered probiotic platform, iRGD‐mRBC@FOLactis, combining red blood cell membrane cloaking and tumor‐penetrating peptide iRGD for enhanced PD‐1 blockade. The platform improves tumor targeting, immune cell activation and therapeutic efficacy in lung cancer, demonstrating significant promise in overcoming PD‐1/PD‐L1 therapy ...
Chen Chen, Junmeng Zhu, Xiao Liu, Jie Shao, Aoxing Chen, Yi Mei, Xinyin Zhang, Qinyi Chen, Lin Li, Baorui Liu   +9 more
wiley   +1 more source

Correction: Factors Affecting the Receptiveness of Chinese Internists and Surgeons Toward Artificial Intelligence-Driven Drug Prescription: Protocol for a Systematic Survey Study.

JMIR Res Protoc
Shen Q, Gong X, Zhang W, Hu Y, Ma Y, Ren Z, Liu S, Song Z, Gale RP, Wang J, Chen J.   +10 more
europepmc   +1 more source

Clinical characteristics and prognostic factors of patients with solitary plasmacytoma: a multicenter retrospective study. [PDF]

Ther Adv Hematol
Shen X, Han W, Zhang L, Jin Y, Lu X, Zhang X, Chen L.   +6 more
europepmc   +1 more source