Results 41 to 50 of about 14,341 (209)

Liver metastasis of breast carcinoma: An unusual presentation and growth pattern

Indian Journal of Pathology and Microbiology, 2023
Breast carcinoma is one of the tumors that frequently metastasize to the liver. Extramedullary hematopoiesis (EMH) usually occurs due to insufficient medullary hematopoiesis.
Mine Özşen, Nesrin Uğraş, Ömer Yerci, Adem Deligönül   +3 more
doaj   +1 more source

Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]

, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto, Piovan, Erich, Tosello, Valeria, Zanovello, Paola   +3 more
core   +1 more source

A case of intrathoracic extramedullary hematopoiesis-associated pleural effusion in a beta-thalassemia intermedia patient and a short literature review

SAGE Open Medical Case Reports
Extramedullary hematopoiesis is a phenomenon that occurs in conditions of ineffective bone marrow function. In the context of thalassemias, extramedullary hematopoiesis is more frequently observed in beta-thalassemia intermedia patients, with thoracic ...
Georgios Petros Barakos, Athanasia Papazafiropoulou, Konstantinos Mihos, Valeria Eminidou, Stefani Andronikou, Lemonia Ainalidou, Niki Mofori, Themis Gkraikou, Georgios Athanasakis, Nikolaos Papanas, Stavros Antonopoulos   +10 more
doaj   +1 more source

Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 [PDF]

, 2014
Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood.
Akinc, Anna Borodovsky, Assmus, Auffray, Chow, Clinton, Coelho, Courties, Dahlman, Dai, Daniel G. Anderson, Ding, Ding, Dutta, Elices, Filip K. Swirski, Florian Leuschner, Frank-Kamenetsky, Friedrich Felix Hoyer, Gabriel Courties, Gregory Wojtkiewicz, Hendrik B. Sager, Hume, Kevin Fitzgerald, Kiel, Kim, Leuschner, Leuschner, Love, Lu, Lubov S. Grigoryeva, Majmudar, Massa, Matthias Nahrendorf, Miyake, Moore, Murphy, Nahrendorf, Nicolas Da Silva, Novobrantseva, Panizzi, Partha Dutta, Peter Libby, Qiao, Rajavashisth, Ralph Weissleder, Rauch, Robbins, Robbins, Rosas, Salomon, Scott, Shaposhnik, Sugiyama, Swirski, Swirski, Swirski, Tagliani, Takahashi, Takizawa, Tatiana Novobrantseva, Trogan, Tsujioka, Ulyanova, van Gils, Vera M. Ruda, Wang, Williams, Winkler, Yona, Yoshiko Iwamoto, Yuan Sun   +71 more
core   +2 more sources

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Extramedullary Hematopoiesis: An Unusual Finding in Subdural Hematomas

Case Reports in Pathology, 2011
We present a case of a 59-year-old man who was found to have clusters of hyperchromatic, small, round nucleated cells within a subdural hematoma removed after a skull fracture.
Rong Li, Vishnu V. B. Reddy, Cheryl Ann Palmer   +2 more
doaj   +1 more source

Repercussion of megakaryocyte-specific Gata1 Loss on megakaryopoiesis and the hematopoietic precursor compartment [PDF]

, 2016
During hematopoiesis, transcriptional programs are essential for the commitment and differentiation of progenitors into the different blood lineages. GATA1 is a transcription factor expressed in several hematopoietic lineages and essential for proper ...
A Dubart, A Mazharian, AH Schuh, AM Vannucchi, Attila Mócsai, B Kehrel, C Yu, CA de Graaf, CA de Graaf, DJ Whyatt, F Lindeboom, F Pertuy, H Harigae, I Brodsky, I Bruns, I Hamlett, IM De Cuyper, Iris M. De Cuyper, J Borg, J Wechsler, JD Crispino, K Drabek, K Freson, K Saijo, K Yomogida, Kevin D Bunting, L Gutierrez, L Gutierrez, Laura Gutiérrez, LJ Ko, M Meinders, M Pimkin, M Socolovsky, M Zingariello, MA McDevitt, Maaike R. Scheenstra, Marjolein Meinders, Mark Hoogenboezem, MC Simon, ME Greene, MJ Weiss, MJ Weiss, MM Zutter, P Rodriguez, P Vyas, Petros Papadopoulos, R Ferreira, R Ferreira, R Tiedt, RA Shivdasani, S Takahashi, SC Hughan, SD Calaminus, SP Watson, Taco W. Kuijpers, Tamás Németh, TD Schmittgen, Timo K. van den Berg, WC Aird, Y Fujiwara, Y Hashimoto   +60 more
core   +3 more sources

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen [PDF]

, 2015
Ames hypopituitary dwarf mice are deficient in growth hormone, thyroid-stimulating hormone, and prolactin. The phenotype of these mice demonstrates irregularities in the immune system with skewing of the normal cytokine milieu towards a more anti ...
Bartke, Andrzej, Broxmeyer, Hal E., Capitano, Maegan L., Chitteti, Brahmananda R., Cooper, Scott, Srour, Edward F.   +5 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source