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Pediatric Hematopoietic Stem Cell Transplant
Pediatrics In Review, 20201. Ellen Fraint, MD* 2. Mary Jo Holuba, MSN, CPNP* 3. Lisa Wray, MD† 1. *Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children’s Hospital at Montefiore, Bronx, NY 2. †Division of Oncology, Children’s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania Perelman School of Medicine ...
Ellen, Fraint +2 more
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Hematopoietic Stem Cell Transplantation in Thalassemia
Hematology/Oncology Clinics of North America, 2018Although recent advances in gene therapy are expected to increase the chance of disease cure in thalassemia major, at present hematopoietic stem cell transplantation (HSCT) remains the only consolidated curative approach for this disorder. The widest experience has been obtained in the HLA-matched family donor (MFD) setting, with probabilities of ...
Strocchio L., Locatelli F.
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Mouse Hematopoietic Stem Cell Transplantation
2013Hematopoietic stem cells (HSCs) are capable of self-renewal and multi-lineage reconstitution of hematopoiesis in irradiated transplant recipient mice. As such, bone marrow transplantation (BMT) is a major assay commonly used to examine murine HSC activity.
Hui, Cheng, Paulina H, Liang, Tao, Cheng
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Fetal hematopoietic stem cell transplantation
Seminars in Perinatology, 1999In utero hematopoietic stem cell transplantation (IUHSCTx) is a promising approach for the treatment of a potentially large number of fetuses affected by congenital hematologic disorders. With technical and molecular advances in prenatal diagnosis, the majority of these diseases can now be diagnosed early in gestation, allowing consideration of ...
A F, Shaaban, A W, Flake
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Hematopoietic Stem Cell Transplantation in Thalassemia
Hematology/Oncology Clinics of North America, 2023Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only consolidated, potentially curative treatment for patients with transfusion-dependent thalassemia major. In the past few decades, several new approaches have reduced the toxicity of conditioning regimens and decreased the incidence of graft-versus-host disease, improving patients'
Mattia, Algeri +2 more
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Hematopoietic stem cell transplantation in infants
Pediatric Blood & Cancer, 2014BackgroundIt is rare for infants, who are less than 365 days old, to receive hematopoietic stem cell transplantation (HSCT). Our objective was to review the indications, survival, and late effects of infants who received HSCT.ProcedureBetween April 1992 and March 2010, a total of 1,363 children underwent HSCT (775 allogeneic [allo]; 588 autologous ...
Adam, Gassas +7 more
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Hematopoietic Stem Cell Transplantation for Thalassemia
Immunotherapy, 2012Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant.
Yasser, Elborai +2 more
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Proteomics for hematopoietic stem cell transplantation
Expert Review of Proteomics, 2020Introduction: After the genomic era, the analysis of the proteome has gained increasing importance. Peptides and/or proteins present in tissue or body fluids can depict health and are prone to change during disease, not only in configuration but also in abundance.
Eva M, Weissinger +4 more
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Hematopoietic Stem Cell Transplantation for Myelofibrosis
Seminars in Oncology, 2005Myelofibrosis with myeloid metaplasia (MMM) is a clonal disorder resulting from the proliferation of aberrant hematopoietic progenitors. Hence MMM is curable if the abnormal clone can be eradicated and replaced by normal cells from healthy donors.
Koen, van Besien, H Joachim, Deeg
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Hematopoietic Stem Cell Transplantation for Thalassemia
Current Stem Cell Research & Therapy, 2009Hematopoietic stem cell transplantation (HSCT) represents the only cure for patients with thalassemia. At present HSCT in younger patients from an HLA- matched sibling donor offers 80% to 87% probability of cure according to risk classes. However, results HSCT in adult patients continue to be inferior due to advanced of disease.
Javid, Gaziev, Guido, Lucarelli
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