Results 111 to 120 of about 193,098 (314)

Natural History and Diagnostic Findings in an Adult Man Diagnosed With Attenuated Krabbe Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Krabbe disease (KD), or globoid cell leukodystrophy, is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in galactocerebrosidase (GALC), leading to psychosine (galactosylsphingosine) accumulation and myelin damage.
Eamon P. McCarron, Andrew Oldham, Amit Herwadkar, Sarah Jenkinson, Christopher Campbell, Kate Neal, Heather J. Church, James A. Cooper, Karolina M. Stepien   +8 more
wiley   +1 more source

B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome [PDF]

, 1999
TG Gross, M. Steinbuch, Todd E. DeFor, RS Shapiro, Philip B. McGlave, NKC Ramsay, JE Wagner, A.H. Filipovich   +7 more
openalex   +1 more source

Second haploidentical bone marrow transplantation with antithymocyte antibody-containing conditioning regimen for graft failure in eight patients with severe aplastic anemia

Scientific Reports
The effects of a second haploidentical bone marrow transplantation with an antithymocyte antibody-containing conditioning regimen after graft failure in patients with severe aplastic anemia remain unclear. Eight severe aplastic anemia patients with graft
Chengtao Zhang, Yutong Hou, Yan Yang, Jingjing Zhang, Xiaoli Zheng, Jinsong Yan   +5 more
doaj   +1 more source

A Multicenter Study of Platelet Recovery and Utilization in Patients After Myeloablative Therapy and Hematopoietic Stem Cell Transplantation [PDF]

, 1998
Steven H. Bernstein, Auayporn Nademanee, Julie M. Vose, Guido Tricot, Joseph W. Fay, Robert S. Negrin, John F. DiPersio, Gabriela Rondón, Richard E. Champlin, Michael J. Barnett, Kenneth Cornetta, Geoffrey P. Herzig, William P. Vaughan, George F. Geils, Armand Keating, Hans A. Messner, Steven N. Wolff, Kenneth B. Miller, Charles Linker, Mitchell S. Cairo, Susan Hellmann, Mark Ashby, Scott Stryker, Richard A. Nash   +23 more
openalex   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Effectiveness of Autologous Hematopoietic Stem Cell Transplantation versus Alemtuzumab and Ocrelizumab in Relapsing Multiple Sclerosis: A Single Center Cohort Study

Annals of Neurology, EarlyView.
Objective To compare clinical and radiological outcomes among relapsing multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT), alemtuzumab (ATZ), and ocrelizumab (OCR). Methods From a London (UK) hospital‐based observational cohort, modeled data were obtained from 621 relapsing–remitting multiple sclerosis ...
Paolo Antonio Muraro, Antonio Zito, Alessio Signori, Maria Pia Sormani, Eleonora Rigoni, Federica Pollidoro, Roberto Bergamaschi, Alice Mariottini, Omar Malik, Ashwini Nandoskar, Victoria Singh‐Curry, Varun Mehra, Majid Kazmi, Ian Gabriel, Eli Silber, Richard Nicholas, Antonio Scalfari   +16 more
wiley   +1 more source

Maribavir Pharmacokinetics and Safety in Participants With Moderate Hepatic Impairment: A Phase 1, Open‐Label, Single‐Dose, Parallel Group Study

The Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 250-258, February 2023., 2023
Abstract Maribavir, an orally bioavailable antiviral, has shown superior activity against posttransplant cytomegalovirus infection compared with conventional antivirals. It is primarily metabolized in the liver. This open‐label, single‐center study evaluated the effect of hepatic impairment on the pharmacokinetics of maribavir in nontransplant ...
Ivy Song, Grace Chen, Jingyang Wu, Katarina Ilic   +3 more
wiley   +1 more source

PB2452: PREVALENCE AND SEVERITY OF COVID-19 IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS IN CHINA

HemaSphere, 2023
Hongye Gao, Jiali Wang, Xinhui Zheng, Yigeng Cao, Aiming Pang, Erlie Jiang   +5 more
doaj   +1 more source

Substitution of Glutamic Acid at Position 71 of DRβ1*04:01 and Collagen‐Specific Tolerance Without Alloreactivity

Arthritis &Rheumatology, EarlyView.
Objective The DRB1 locus is strongly associated with both susceptibility and resistance to rheumatoid arthritis (RA). DRB1 alleles encoding the VKA or VRA epitope in positions 11, 71, and 74 confer the highest risk of developing RA, whereas the allele encoding VEA is protective.
Vibha Jha, Brian M. Freed, Elizabeth R. Sunderhaus, Jessica E. Lee, Edward B. Prage, Manjula Miglani, Edward F. Rosloniec, Jennifer L. Matsuda, Marilyne G. Coulombe, Amy S. McKee, Christina L. Roark   +10 more
wiley   +1 more source

Reduced exercise capacity is associated with left ventricular systolic dysfunction in long‐term survivors of allogeneic hematopoietic stem‐cell transplantation

Journal of Clinical Ultrasound, Volume 51, Issue 1, Page 5-15, January 2023., 2023
Exercise intolerance is a common complication in long‐term survivors of allogeneic hematopoietic stem‐cell transplantation. In this study, we found reduced oxygen uptake (VO2peak) by cardio‐pulmonary exercise tests to be associated with left ventricular systolic dysfunction by echocardiography.
Richard John Massey, Ole Henrik Myrdal, Phoi Phoi Diep, Marta Maria Burman, Lorentz Brinch, Lars Lysgaard Gullestad, Ellen Ruud, Svend Aakhus, Jan Otto Beitnes   +8 more
wiley   +1 more source