A survey on cellular and engineered tissue therapies in Europe in 2008 [PDF]
, 2010 Cellular therapy is an evolving investigational treatment modality in regenerative medicine, but little published information is available on its current use.
Baldomero, Helen +4 more
core +1 more source
Natural History and Diagnostic Findings in an Adult Man Diagnosed With Attenuated Krabbe Disease
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Krabbe disease (KD), or globoid cell leukodystrophy, is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in galactocerebrosidase (GALC), leading to psychosine (galactosylsphingosine) accumulation and myelin damage.
Eamon P. McCarron +8 more
wiley +1 more source
Journal of Translational Medicine, 2017 Background As one of the major treatment obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), relapse of Ph+ALL may result from the persistence of leukemia-propagating cells (LPCs).
Yuan Kong +10 more
doaj +1 more source
Periodic solutions for a nonautonomous mathematical model of hematopoietic stem cell dynamics [PDF]
arXiv, 2020 The main purpose of this paper is to study the existence of periodic solutions for a nonautonomous differential-difference system describing the dynamics of hematopoietic stem cell (HSC) population under some external periodic regulatory factors at the cellular cycle level.
arxiv
Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency [PDF]
, 2014 Defects in perforin lead to the failure of T and NK cell cytotoxicity, hypercytokinemia, and the immune dysregulatory condition known as familial hemophagocytic lymphohistiocytosis (FHL).
Alonso-Ferrero, ME +13 more
core +2 more sources
Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides Demonstrates Different Alloreactivity Potential In HLA-Matched and Mismatched Donor-Recipient Pairs [PDF]
arXiv, 2015 Stem cell transplants may be considered as dynamical systems to allow sequence differences across the exomes of the transplant donors and recipients to be used to simulate an alloreactive T cell response. Whole exome sequencing was performed on HLA matched stem cell transplant donor-recipient pairs, and the nucleotide sequence differences translated to
arxiv
Journal of the American Medical Association (JAMA), 2014 IMPORTANCE Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults.
M. Hsieh +10 more
semanticscholar +1 more source
Individual quality assessment of autografting by probability estimation for clinical endpoints: a prospective validation study from the European group for blood and marrow transplantation. [PDF]
, 2013 The aim of supportive autografting is to reduce the side effects from stem cell transplantation and avoid procedure-related health disadvantages for patients at the lowest possible cost and resource expenditure.
Campioni, Dc +19 more
core +1 more source
Hematopoietic stem cell transplantation in Thailand [PDF]
Bone Marrow Transplantation, 2008 Hematopoietic SCT was first performed in Thailand in 1986. At present, there are FOUR active centers: Siriraj, Ramathibodi, Chulalongkorn and Pramongkutklao Hospitals. The annual number of transplants varies from 120 to 150 cases. Although the number of eligible patients is high, only a proportion of the patients can undergo hematopoietic SCT due to ...
openaire +3 more sources