Results 201 to 210 of about 540,232 (408)

Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency

open access: yesHead &Neck, EarlyView.
ABSTRACT Background GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.
Brejjette Aljabi   +3 more
wiley   +1 more source

Future directions in haploidentical hematopoietic stem cell transplantation

open access: yesHematology
Outcomes of haploidentical hematopoietic stem cell transplantation (haplo-SCT) have improved over time. Graft failure and graft-versus-host disease (GVHD), which were important complications in major human leukocyte antigen (HLA)-disparity stem cell ...
Pongthep Vittayawacharin   +2 more
doaj   +1 more source

Immunologic responses to the third and fourth doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in cell therapy recipients: a systematic review and meta-analysis

open access: yesVirology Journal
Background Multiple studies have provided evidence of suboptimal or poor immune responses to SARS-CoV-2 vaccines in recipients of hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor-T (CAR-T) cell therapy compared to healthy ...
Leyla Sharifi Aliabadi   +9 more
doaj   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner   +3 more
wiley   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner   +7 more
wiley   +1 more source

A special report: histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors

open access: hybrid, 1999
Carolyn Katovich Hurley   +12 more
openalex   +1 more source

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