Results 361 to 370 of about 540,232 (408)

Genomic variant profiling in blast‐phase paediatric chronic myeloid leukaemia: Predisposing and driving alterations

open access: yesBritish Journal of Haematology, EarlyView.
To identify pathogenic somatic and germline gene variants associated with blast‐phase transformation and cancer predisposition in paediatric chronic myeloid leukaemia (CML), n = 19 patients with blast‐phase paediatric CML were analysed with whole genome and targeted panel sequencing and compared to n = 19 patients with chronic phase paediatric CML.
Yvonne Lisa Behrens   +22 more
wiley   +1 more source

The role of blinatumomab in adult acute B lymphoblastic leukaemia

open access: yesBritish Journal of Haematology, EarlyView.
Blinatumomab, a CD19‐directed bispecific T‐cell engager, has become a crucial part of BCP‐ALL therapy in r/r disease, MRD‐positive disease and has recently been implemented into first‐line therapy of BCP‐ALL. This review discusses important clinical trials with a focus on blinatumomab in first‐line therapy of adult BCP‐ALL.
Anne C. Wilke, Nicola Gökbuget
wiley   +1 more source

The progression of multiple myeloma is regulated by LILRB1 via the GATA2–SAGE1 pathway

open access: yesBritish Journal of Haematology, EarlyView.
Summary Multiple myeloma (MM) is a haematological malignancy characterized by the clonal expansion of plasma cells within the bone marrow, thus resulting in the overproduction of monoclonal immunoglobulins. Despite the availability of various immunotherapeutic strategies, patient survival rates remain disappointingly low, thus underscoring the need for
Chiqi Chen   +8 more
wiley   +1 more source

Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis. [PDF]

open access: yesNat Commun
Schäfersküpper M   +11 more
europepmc   +1 more source

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