Results 51 to 60 of about 461,308 (260)

Nanographene Oxide Attenuates Acute GVHD by Modulating Macrophage Polarization in a Xenogeneic Mouse Model

Advanced Science, EarlyView.
Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu, Hyun Sung Park, Dong‐Hoon Chae, Jae Han Park, Jiyoung Heo, Keonwoo Cho, Jiho Kim, Hyewon Lee, Sueyeon Jee, Chanwoo Kim, Soon Won Choi, Jaechul Ryu, Eun‐Hye Hur, Yunsuk Choi, Eun‐Ji Choi, Mi‐Kyung Oh, Hwa‐Yong Lee, Je‐Hwan Lee, Kyung‐Rok Yu   +18 more
wiley   +1 more source

Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT [PDF]

, 2018
Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL). Recently, haploidentical HCT is gaining interest because of better outcomes with post-transplantation ...
Beelen, Dietrich, Bittenbring, Jörg, Blaise, Didier, Blok, Henric-Jan, Castagna, Luca, Chevallier, Patrice, Ciceri, Fabio, Corradini, Paolo, Eikema, Dirk-Jan, Foá, Roberto, Hallek, Michael, Hilgendorf, Inken, Koc, Yener, Kröger, Nicolaus, Moreno, Carol, Müller, Lutz Peter, Schetelig, Johannes, Selleslag, Dominik, Solano, Carlos, Theobald, Matthias, Tischer, Johanna, van Gelder, Michel, van Gorkom, Gwendolyn, van Lint, M. T.   +23 more
core   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

The early expansion of anergic NKG2Apos/CD56dim/CD16neg natural killer represents a therapeutic target in haploidentical hematopoietic stem cell transplantation

Haematologica, 2018
Natural killer cells are the first lymphocyte population to reconstitute early after non-myeloablative and T cell-replete haploidentical hematopoietic stem cell transplantation with post-transplant infusion of cyclophosphamide.
A. Roberto, C. Di Vito, Elisa Zaghi, E. Mazza, A. Capucetti, M. Calvi, P. Tentorio, V. Zanon, B. Sarina, J. Mariotti, S. Bramanti, E. Tenedini, E. Tagliafico, S. Bicciato, A. Santoro, M. Roederer, E. Marcenaro, L. Castagna, E. Lugli, D. Mavilio   +19 more
semanticscholar   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

Impaired bone marrow homing of cytokine-activated CD34⁺ cells in the NOD/SCID model [PDF]

, 2004
The reduced engraftment potential of hematopoietic stem/progenitor cells (HSPCs) after exposure to cytokines may be related to the impaired homing ability of actively cycling cells. We tested this hypothesis by quantifying the short-term horning of human
Ahmed, F, Blundell, MP, Fahey, A, Ings, SJ, Linch, DC, Pizzey, AR, Thrasher, AJ, Ye, HT, Yong, KL   +8 more
core  

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques. [PDF]

, 2015
BACKGROUND:How a potentially diverse population of hematopoietic stem cells (HSCs) differentiates and proliferates to supply more than 10(11) mature blood cells every day in humans remains a key biological question.
Chen, Irvin SY, Chou, Tom, Goyal, Sidhartha, Kim, Sanggu   +3 more
core   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation

Advanced Science, EarlyView.
MSC‐EVs alleviate peritoneal inflammation and fibrogenesis by disrupting the H3K18la‐CCL2 axis and crosstalk between mesothelial cells and Ly6c2⁺ macrophages. Model cartoons are constructed using the Biorender website (https://www.biorender.com/), and a usage license is obtained. Abstract Peritoneal dialysis (PD), as a renal replacement therapy, relies
Qiang Huang, Yuxiang Sun, Pengpeng Kuang, Juan Sun, Dandan Guo, Long Peng, Hu Zhou, Qinrong Song, Zhihao Huo, Canming Li, Janusz Witowski, Zhaoyong Hu, Hui Peng   +12 more
wiley   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source