Results 71 to 80 of about 382,649 (338)

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Novel_circ_003686 regulates the osteogenic differentiation of MSCs in patients with myeloma bone disease through miR-142-5p/IGF1 axis

Journal of Bone Oncology, 2023
Objectives: Circ_003686 is a novel_circRNA with abnormally low expression found in the samples of multiple myeloma bone disease (MBD) patients. The current research intended to investigate the effects of novel_circ_003686 in osteogenesis-induced ...
Ling Qiu, Lei Ma, Dan Chen, Nan Zhang, Jiao Cai, Qian Zhang, Xiao Wang, Hai Yi, Hao Yao, Fang-Yi Fan   +9 more
doaj  

Hematopoietic Stem Cell Transplantation in Thalassemia

Hematology, 2010
AbstractAlmost 30 years have passed since the first successful hematopoietic stem cell transplantation in thalassemia and that first patient is now a healthy young adult with a completely normal life. Since that time, more than 3000 such transplants have been performed worldwide.
openaire   +4 more sources

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source

Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.

Journal of the American Medical Association (JAMA), 2014
IMPORTANCE High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small phase 2 trials.
J. V. van Laar, D. Farge, J. Sont, K. Naraghi, Z. Marjanovic, J. Larghero, A. Schuerwegh, E. Marijt, M. Vonk, A. Schattenberg, M. Matucci-Cerinic, A. Voskuyl, A. A. van de Loosdrecht, T. Daikeler, I. Kötter, M. Schmalzing, T. Martin, B. Lioure, S. Weiner, A. Kreuter, C. Deligny, J. Durand, P. Emery, K. Machold, F. Sarrot-Reynauld, K. Warnatz, D. Adoue, J. Constans, H. Tony, N. Del Papa, A. Fassas, A. Himsel, D. Launay, A. Lo Monaco, P. Philippe, I. Quéré, É. Rich, R. Westhovens, B. Griffiths, R. Saccardi, F. V. D. van den Hoogen, W. Fibbe, G. Socié, A. Gratwohl, A. Tyndall   +44 more
semanticscholar   +1 more source

Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand

Advanced Science, EarlyView.
Bone‐specific endothelial cells (b‐ECs) uniquely express KITLG, which recruits c‐Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (bm‐MSCs) and subsequent ossification.
Xiang Li, Hwan D. Kim, Allen C. Luo, Liyan Gong, Yonglin Zhu, Chin Nien Lee, Xuechong Hong, Christopher L. Sudduth, Michal Ad, Young‐Hyeon An, Mihn Jeong Park, Do‐Gyoon Kim, Arin K. Greene, Bonnie L. Padwa, Nathaniel S. Hwang, Ruei‐Zeng Lin, Juan M. Melero‐Martin   +16 more
wiley   +1 more source

Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

Frontiers in Immunology, 2017
The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte ...
A. Dickinson, J. Norden, Shuang Li, I. Hromadníková, C. Schmid, H. Schmetzer, Hans Jochem-Kolb   +6 more
semanticscholar   +1 more source

Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy

Advanced Science, EarlyView.
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley   +1 more source

A Complementarity‐Based Approach to De Novo Binder Design

Advanced Science, EarlyView.
A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko, Valeriia Hatskovska, Murray Coles, Narges Aghaallaei, Natalia Pashkovskaia, Natalia Borbarán‐Bravo, Matteo Pilz, Philip Bucher, Mareike Volz, Joana Pereira, Marcus D. Hartmann, Ghazaleh Tabatabai, Judith Feucht, Stefan Liebau, Patrick Müller, Andrei N. Lupas, Julia Skokowa, Mohammad ElGamacy   +17 more
wiley   +1 more source

Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation.

Clinical Infectious Diseases, 2012
BACKGROUND Bacteremia is a frequent complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It is unclear whether changes in the intestinal microbiota during allo-HSCT contribute to the development of bacteremia.
Y. Taur, J. Xavier, Lauren Lipuma, C. Ubeda, J. Goldberg, Asia Gobourne, Yeon Joo Lee, K. Dubin, N. Socci, A. Viale, M. Perales, R. Jenq, M. V. D. van den Brink, E. Pamer   +13 more
semanticscholar   +1 more source