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Hematopoietic Stem-Cell Transplantation
New England Journal of Medicine, 2006Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically.
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Neovascularization and Hematopoietic Stem Cells
Cell Biochemistry and Biophysics, 2011Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies
Jingwei, Lu +2 more
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Hematopoietic stem cells: An overview
Transfusion and Apheresis Science, 2014Considerable efforts have been made in recent years in understanding the mechanisms that govern hematopoietic stem cell (HSC) origin, development, differentiation, self-renewal, aging, trafficking, plasticity and transdifferentiation. Hematopoiesis occurs in sequential waves in distinct anatomical locations during development and these shifts in ...
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Hematopoietic Stem Cell Transplantation
Hospital Practice, 1993The isolation, purification, and in vitro expansion of the hematopoietic stem cell have allowed pretransplant immunologic and genetic manipulation. As a result, rapid allogeneic or autologous hematologic reconstitution with minimal graft-versus-host disease is possible in patients receiving high-dose chemotherapy.
S, Jagannath, B, Barlogie, G, Tricot
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The aging of hematopoietic stem cells
Nature Medicine, 1996We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle-aged mice. Single, reconstituting HSCs (by limit dilution) from old and young mice exhibited indistinguishable progenitor activities in vivo. HSCs were five times as frequent in the bone marrow of old mice; however,
S J, Morrison +4 more
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The biology of hematopoietic stem cells
Archives of Medical Research, 2003Rarely has so much interest from the lay public, government, biotechnology industry, and special interest groups been focused on the biology and clinical applications of a single type of human cell as is today on stem cells, the founder cells that sustain many, if not all, tissues and organs in the body.
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The Biology of Hematopoietic Stem Cells
Annual Review of Cell and Developmental Biology, 1995Hematopoietic stem cells (HSC) are the only cells in the blood-forming tissues that can give rise to all blood cell types and that can self-renew to produce more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short- and long-term reconstituting effects ...
S J, Morrison, N, Uchida, I L, Weissman
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Thrombopoietin and the Hematopoietic Stem Cell
Blood, 1998Abstract: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, selfârenewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways.
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Purification and characterization of mouse hematopoietic stem cells.
Science, 1988G. Spangrude, S. Heimfeld, I. Weissman
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Expansion of primitive human hematopoietic stem cells by culture in a zwitterionic hydrogel
Nature Medicine, 2019T. Bai +16 more
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