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Nanotechnology-based platforms for effective and versatile sonodynamic therapy in cancer treatment. [PDF]

Nanomedicine (Lond)
McHale AP, Nomikou N.
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Light-induced transformations of hematoporphyrin diacetate and hematoporphyrin

Journal of Photochemistry and Photobiology B: Biology, 1988
Illumination of hematoporphyrin diacetate (HP-Diac) and hematoporphyrin (HP) in phosphate-buffered solutions causes the formation of a stable photoproduct absorbing at 636 nm. Simultaneously the photo-oxidation of HP-Diac and HP takes place. These phototransformations depend on the illumination dose and the concentration of the HP-Diac or HP solution ...
Ricardas Rotomskis, Gediminas Jonusauskas   +1 more
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Zinc hematoporphyrin in preparations of hematoporphyrin and hematoporphyrin derivative

Chemical Physics Letters, 1984
Abstract The blue-shifted emission from aged aqueous solutions of hematoporphyrin and its derivatives, reported by others to originate from special aggregates, is shown to originate from the zinc chelates of the porphyrins. Suggestions are made regarding the role of such zinc porphyrins in the localization of hematoporphyrin and its derivatives in ...
A.A. Lamola, M. Sassaroli
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Hematoporphyrin Derivative Photoradiation Therapy

Archives of Ophthalmology, 1984
To the Editor. —I read with interest the article in the JulyArchivesregarding hematoporphyrin derivatives in photoradiation therapy. 1 I found a number of references to this subject appearing in the literature. When I introduced porphyrins to clinical medicine in 1955, at the Johns Hopkins Hospital, Baltimore, 2 I originally used it as a surgical tool.
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Hematoporphyrin and hematoporphyrin-derivative photosensitization of mitochondria

Biochimie, 1986
Laser micro-irradiation experiments show that mitochondria are profoundly affected when cells are irradiated with Hp as the photosensitizer. Functional as well as enzymatic studies on isolated mitochondria show that coupling between respiration and oxidative phosphorylation, Ca2+ transport and respiration are successively lost under irradiation in the ...
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Tumor Fluorescence with Hematoporphyrin Derivative

Annals of Otology, Rhinology & Laryngology, 1977
Hematoporphyrin derivative (HpD) is one of several photodynamically active dyes that accumulate in tumor cells and can be used to differentiate neoplastic from normal tissue by violet light activation. Degree of tumor fluorescence was studied in relation to the nature of the hematoporphyrin compound, dose of HpD injected, route of injection, and ...
R J, Carpenter, H B, Neel, R J, Ryan, D R, Sanderson   +3 more
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Bronchoscopic Phototherapy Using Hematoporphyrin Derivative

Surgical Clinics of North America, 1984
Phototherapy in the presence of hematoporphyrin (HPD) produces cytotoxicity through both energy- and power-dependent mechanisms. The resulting cellular death demonstrates the promise of HPD in the therapy of small cancers. This article reports our clinical experience and follow-up results of treating 19 patients with cancer of the tracheobronchial tree,
D A, Cortese, J H, Kinsey
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Fluorescence spectra of hematoporphyrin and hematoporphyrin-diacetate aggregates in buffer solution

Journal of Photochemistry and Photobiology B: Biology, 1989
Different fluorescence spectra are observed on preferential excitation of monomer and aggregate species of hematoporphyrin and hematoporphyrin-diacetate, respectively. From these measurements we obtain the fluorescence spectrum of aggregate species in buffer solution, which shows two maxima, at 628 nm and around 700 nm.
R, Rotomskis, E J, van de Meent, T J, Aartsma, A J, Hoff   +3 more
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Photophysics and Photochemistry of Hematoporphyrin, Hematoporphyrin Derivative and Uroporphyrin I

1985
The putative action mechanism in photodynamic therapy (PDT) involves serum transport of HPD to tumor tissue, localization and retention of the active constituent, generation of singlet molecular oxygen (Δ) by the action of visible light and the attack of t on the cellular targets.
L I, Grossweiner, A, Blum, G C, Goyal
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Pharmacokinetic Studies of Hematoporphyrin Derivatives on Rat Hepatocytes. Protoporphyrin Dimethyl Ester Hematoporphyrin Ether versus Dihematoporphyrin Ether-Free Hematoporphyrin Derivative

Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both, H, Häberlein, A M, Gressner, I, Sieg, M O, Doss   +4 more
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