Results 21 to 30 of about 27,519 (222)
HFE-Associated Hereditary Haemochromatosis [PDF]
Canadian Journal of Gastroenterology, 2000 Hereditary hemochromatosis is a common inherited disorder of the iron metabolism. Screening studies indicate that it has a prevalence of one in 200 to 400, depending on the population studied, and a carrier rate of about one in seven to one in 10.
Emmeke J Eijkelkamp +2 more
doaj +3 more sources
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Liver Transplantation, EarlyView., 2022 Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala +6 more
wiley +1 more source
The Arthropathy of Hemochromatosis Without Hemochromatosis [PDF]
Arthritis & Rheumatism, 1973 AbstractA 65‐year‐old man and his 62‐year‐old sister presented with joint pains and were found to have chondrocalcinosis. Both had elevations of serum iron and an increased saturation of iron binding protein. Biopsies revealed hemosiderin deposits in the parenchymal cells of the liver of both patients and the lining cells of the synovium of one ...
D A, Gordon, H A, Little
openaire +2 more sources
Hemochromatosis-like disease in Brazilian tapirs (Tapirus terrestris) in Pará state, Brazil
, 2022 We report two cases of hemochromatosis-like disease in captive Brazilian tapirs, Tapirus terrestris in Pará state, Brazil. Both animals presented symptoms of chronic hepatopathy associated with marked accumulation of hemosiderin.
Rosekelly de Jesus CARDOSO (14224421) +11 more
core +1 more source
Biochemical, Biophysical, and Cellular Investigations of the Interactions of Transferrin Receptor with Transferrin and the Hereditary Hemochromatosis Protein, HFE [PDF]
, 2004 Hereditary hemochromatosis (HH) is a prevalent genetic disorder that results in the daily excess absorption of dietary iron. If untreated this disease leads to systemic organ failure and death. HH is caused by mutations to the gene coding for a protein
Giannetti, Anthony Michael
core +1 more source
Biophysical and Cell Biological Studies Characterizing the Vertebrate Iron Exporter Ferroportin [PDF]
, 2009 Mammalian iron homeostasis is maintained by an intricate network of diverse proteins that constantly survey systemic iron levels and carefully regulate the uptake of iron from the diet. Control of this uptake is critically important because once iron is
Rice, Adrian Edward
core +1 more source
Ferroportin disease: pathogenesis, diagnosis and treatment
Haematologica, 2017 Ferroportin Disease (FD) is an autosomal dominant hereditary iron loading disorder associated with heterozygote mutations of the ferroportin-1 (FPN) gene.
Antonello Pietrangelo
doaj +1 more source
Prognostic Factors and Survival in Patients with Hereditary Hemochromatosis and Cirrhosis
Canadian Journal of Gastroenterology, 2006 OBJECTIVES: The survival of treated, noncirrhotic patients with hereditary hemochromatosis is similar to that of the general population. Less is known about the outcome of cirrhotic hereditary hemochromatosis patients.
Melanie D Beaton, Paul C Adams
doaj +1 more source