Results 21 to 30 of about 25,688 (240)

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Unusual Colonic Iron Deposition Following Prophylactic Supplementation in an Infant: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Iron plays a vital role in physiological functions, and its deposition is typically limited to reticuloendothelial tissues in the presence of excess levels. We report a rare case of colonic iron deposition in a 13‐month‐old child without iron overload or toxicity. Despite a normal serum iron profile and administration of only prophylactic iron
Imanzadeh F, Heidari MM, Madani SR, Mahjoub F, Jameie S.   +4 more
europepmc   +2 more sources

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

The Arthropathy of Hemochromatosis Without Hemochromatosis [PDF]

Arthritis & Rheumatism, 1973
AbstractA 65‐year‐old man and his 62‐year‐old sister presented with joint pains and were found to have chondrocalcinosis. Both had elevations of serum iron and an increased saturation of iron binding protein. Biopsies revealed hemosiderin deposits in the parenchymal cells of the liver of both patients and the lining cells of the synovium of one ...
D A, Gordon, H A, Little
openaire   +2 more sources

Hemochromatosis-like disease in Brazilian tapirs (Tapirus terrestris) in Pará state, Brazil

, 2022
We report two cases of hemochromatosis-like disease in captive Brazilian tapirs, Tapirus terrestris in Pará state, Brazil. Both animals presented symptoms of chronic hepatopathy associated with marked accumulation of hemosiderin.
Rosekelly de Jesus CARDOSO (14224421), Pedro Soares BEZERRA JUNIOR (14224442), Alessandra Scofield AMARAL (14224445), Natalia Maxine F. P. SARMENTO (14224424), Valíria Duarte CERQUEIRA (14224448), Gerson Bladimir Escobar GONZALEZ (14224433), Gabriela RIET-CORREA (14224436), Manoel Ananis Lopes SOARES (14224439), Márcio Alan Oliveira MOURA (14224430), Arieli Sousa de OLIVEIRA (14224427), Adrielli Heloise dos Anjos LIMA (14224415), Américo Meirelles NETO (14224418)   +11 more
core   +1 more source

Biochemical, Biophysical, and Cellular Investigations of the Interactions of Transferrin Receptor with Transferrin and the Hereditary Hemochromatosis Protein, HFE [PDF]

, 2004
Hereditary hemochromatosis (HH) is a prevalent genetic disorder that results in the daily excess absorption of dietary iron. If untreated this disease leads to systemic organ failure and death. HH is caused by mutations to the gene coding for a protein
Giannetti, Anthony Michael
core   +1 more source

Biophysical and Cell Biological Studies Characterizing the Vertebrate Iron Exporter Ferroportin [PDF]

, 2009
Mammalian iron homeostasis is maintained by an intricate network of diverse proteins that constantly survey systemic iron levels and carefully regulate the uptake of iron from the diet. Control of this uptake is critically important because once iron is
Rice, Adrian Edward
core   +1 more source

A “Mix and Match” in Hemochromatosis—A Case Report and Literature Focus on the Liver

Medicina, 2023
Hemochromatosis is a genetic disorder characterized by increased iron storage in various organs with progressive multisystemic damage. Despite the reports dating back to 1865, the diagnosis of hemochromatosis poses a challenge to clinicians due to its ...
Claudia Oana Cobilinschi, Ioana Săulescu, Simona Caraiola, Andra Florina Nițu, Radu Lucian Dumitru, Ioana Husar-Sburlan, Andra Rodica Bălănescu, Daniela Opriș-Belinski   +7 more
doaj   +1 more source

Prognostic Factors and Survival in Patients with Hereditary Hemochromatosis and Cirrhosis

Canadian Journal of Gastroenterology, 2006
OBJECTIVES: The survival of treated, noncirrhotic patients with hereditary hemochromatosis is similar to that of the general population. Less is known about the outcome of cirrhotic hereditary hemochromatosis patients.
Melanie D Beaton, Paul C Adams
doaj   +1 more source