Results 11 to 20 of about 11,695 (163)

Pharmacological prolyl hydroxylase inhibition enhances high-intensity exercise capacity in mice. [PDF]

Physiol Rep
Abstract Increased blood hemoglobin concentration theoretically promotes oxygen delivery to the periphery. Clinically, in addition to recombinant human erythropoietin analogs, prolyl hydroxylase (PH) inhibitors to stabilize the expression of hypoxia‐inducible factor (HIF) protein were recently approved for the treatment of anemia in chronic kidney ...
Takemura K, Odawara M, Nishi H, Higashihara T, Yoshida Y, Nakazato K, Fujii NL, Ishii N, Inagi R, Tanaka T, Nangaku M.   +10 more
europepmc   +2 more sources

Addressing Anemia in High‐Altitude Populations: Global Impact, Prevalence, Challenges, and Potential Solutions

American Journal of Hematology, EarlyView.
Key challenges in diagnosing anemia in high‐altitude populations include variability in hemoglobin (Hb) concentration, associated pathological conditions, altitude‐induced plasma volume changes, and environmental factors such as contamination and nutrition.
Ayoub Boulares, Nicola Luigi Bragazzi, Gustavo F. Gonzales, Paul Robach, Benoit Champigneulle, Julien V. Brugniaux, Emeric Stauffer, Elie Nader, Stéphane Doutreleau, Philippe Connes, Samuel Verges, Aurélien Pichon   +11 more
wiley   +1 more source

Clinical validation of a real‐time machine learning‐based system for the detection of acute myeloid leukemia by flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Machine‐learning (ML) models in flow cytometry have the potential to reduce error rates, increase reproducibility, and boost the efficiency of clinical labs. While numerous ML models for flow cytometry data have been proposed, few studies have described the clinical deployment of such models.
Lauren M. Zuromski, Jacob Durtschi, Aimal Aziz, Jeffrey Chumley, Mark Dewey, Paul English, Muir Morrison, Keith Simmon, Blaine Whipple, Brendan O'Fallon, David P. Ng   +10 more
wiley   +1 more source

A contemporary simple risk score for prediction of severe acute kidney injury after heart transplantation

ESC Heart Failure, Volume 12, Issue 2, Page 1166-1175, April 2025.
A contemporary simple risk score for prediction of severe AKI after HT. Abstract Background The aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.
Shuangshuang Zhu, Weihua Qiao, Yixuan Wang, Ying Zhou, Yin Xu, Shijie Wang, Tian Xia, Guohua Wang, Si Chen, Jiawei Shi, Nianguo Dong   +10 more
wiley   +1 more source

Paracentesis outcomes from a medicine procedure service at a tertiary care transplant center

Journal of Hospital Medicine, EarlyView.
Abstract Background Paracentesis is a commonly performed procedure with overall low complication rates. There is a paucity of modern data investigating outcomes for inpatients using standardized point of care ultrasound. Objectives We aimed to evaluate complication rates and outcomes of paracentesis in patients in the inpatient setting of a large ...
Pete Meliagros, Benjamin Chopski, Matthew Ambrosio, Stanley Liu, Somaya Albhaisi, Lana Petrova, Evan Ritter, Adam Garber   +7 more
wiley   +1 more source

Volume kinetics of lactated Ringer's solution in adult horses

Equine Veterinary Journal, EarlyView.
Abstract Background Fluid therapy in horses is primarily empirical. Evidence‐based quantification of the disposition of intravenous (IV) crystalloids used in clinical practice could enhance the effectiveness of fluid therapy. Objectives To determine the pharmacokinetics (i.e., volume kinetics: VK) and associated haemodynamic effects of IV lactated ...
William W. Muir, Xiu Ting Yiew, Shane W. Bateman, Robert G. Hahn   +3 more
wiley   +1 more source

The Impact of Vatinoxan on the Concentrations of Medetomidine, Midazolam, and Fentanyl in Central Nervous System After Subcutaneous Co‐Administration in Rats

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Our aim was to investigate whether vatinoxan, a peripherally acting alpha2‐adrenoceptor antagonist, would affect the concentrations of medetomidine, midazolam, and fentanyl in the central nervous system after subcutaneous co‐administration. Twelve healthy male Wistar rats, aged between 13 and 15 weeks, were used in this study.
Juhana Honkavaara, Emily Lindh, Anna Meller, Karoliina Alm, Marja R. Raekallio, Pernilla Syrjä   +5 more
wiley   +1 more source

Impacts of a Homestead Food Production Intervention on Anaemia and Micronutrient Deficiencies Among Women and Children in Rural Bangladesh: A Cluster‐Randomized Controlled Trial

Maternal &Child Nutrition, EarlyView.
The Food and Agricultural Approaches to Reducing Malnutrition (FAARM) trial found no evidence that a 3‐year Homestead Food Production intervention reduced anaemia or micronutrient deficiencies among women and young children in rural Bangladesh. The intervention had improved diets and hygiene practices, but bigger changes may be needed.
Amanda S. Wendt, Jillian L. Waid, Anna A. Müller‐Hauser, Nathalie J. Lambrecht, Tarique Md. Nurul Huda, Nicholas N. A. Kyei, Sabine Gabrysch   +6 more
wiley   +1 more source

Diet in Pregnancy: A Review of Current Challenges and Recommendations. A British Nutrition Foundation Briefing Paper

Nutrition Bulletin, EarlyView.
ABSTRACT Pregnancy is a crucial period during which maternal nutrition, weight and lifestyle behaviours have a direct impact on both maternal and fetal health. This briefing paper describes dietary and lifestyle recommendations for women during the preconceptional period and throughout pregnancy, identifying specific factors that can be modified to ...
Kathryn H. Hart, Alyson J. Hill, Javier T. Gonzalez, Anne de la Hunty, Alison M. Gallagher, Sara A. Stanner   +5 more
wiley   +1 more source

Acute ketone monoester ingestion lowers resting cerebral blood flow: a randomized cross‐over trial

The Journal of Physiology, EarlyView.
Abstract figure legend This double‐blind, placebo‐controlled, randomized cross‐over trial investigated the effects of ketone monoester (KME) ingestion on resting cerebral blood flow (CBF) in young adults. We demonstrate that KME supplementation lowers CBF in a dose‐dependent manner over 2‐houra post‐ingestion, whereas CBF remained unchanged following ...
Aedan J. Rourke, Claudia M.S. Yong, Geoff B. Coombs, Addriana R. Odisho, Jenna A. Nash, Jack Bone, Baraa K. Al‐Khazraji, Jeremy J. Walsh   +7 more
wiley   +1 more source