Results 71 to 80 of about 2,813,671 (291)

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. [PDF]

, 2014
OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.
Vitón-Castillo, Adrián Alejandro, Mebazaa, A, Mebazaa, A. (Alexandre), Antonelli, M, Rhodes, A. (Andrew), Backer, D. (Daniel) de, Pinsky, MR, Teboul, JL, Bakker, J. (Jan), Vincent, JL, Pinsky, Michaël, Christoph Hofer, Jean Louis Vincent, Teboul, J.L. (Jean Louis), Beale, R, Daniel De Backer, Jaeschke, R, Rhodes, A, Jaeschke, Roman, Hofer, C, Jaeschke, R. (Roman), Teboul, Jean Louis, Mebazaa, Alexandre, Cecconi, M. (Maurizio), De Backer, Daniel, Antonelli, Massimo, Massimo Antonelli, Antonelli, M. (Massimo), Viruez-Soto, José Antonio, Bakker, Jan, Hofer, C. (Christoph), Auza-Santivañez, Jhossmar Cristians, Maurizio Cecconi, Vincent, J.-L. (Jean-Louis), Jean Louis Teboul, Roman Jaeschke, Beale, R. (Richard), Vincent, Jean Louis, Hofer, Christoph, Pinsky, M.R. (Michael), Michael R. Pinsky, Bakker, J, Richard Beale, Rhodes, Andrew, Alexandre Mebazaa, Luperón Loforte, Daysi, Cecconi, M, De Backer, D, Jan Bakker, Beale, Richard, Bakker, Jan; id_orcid, Cecconi, Maurizio, Andrew Rhodes, Томчук, М. А., Урлапова, Д. П., Урлапова, М. П., Urlapova, M. P., Urlapova, D. P.   +57 more
core   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Research priorities in perioperative fluid therapy and hemodynamic monitoring: A Delphi Consensus Survey from the Fluid Therapy and Hemodynamic Monitoring Subcommittee of the Hemostasis, Transfusion Medicine and Fluid Therapy Section (SHTF) of the Spanish Society of Anesthesiology and Critical Care (SEDAR)

, 2023
20.500.12530/87909Background: Research on perioperative fluid therapy and hemodynamic monitoring is difficult and expensive. The objectives of the present study were to summarize and prioritize these issues, in order of research importance.
Mojarro, I., de Nadal, M., Colomina, M. J., Lorente, J. V., Clau-Terre, F., Escarraman, D., Basora, M., Aldecoa, C., Jover-Pinillos, J. L., Lopez, I. J., Perez, A., Ferrandis-Comes, R., Garruti, I., Yanes, G., Alonso-Cabello, J., Tome-Roca, J. L., Cota-Delgado, F., Monge-Garcia, M. I., del Cojo-Peces, E., Ripolles-Melchor, J., Llau-Pitarch, J. V., Ramasco, F., Garcia-Lopez, D., Una-Orejon, R., Alonso-Inigo, J. M., Aya, H., Montesinos-Fadrique, S. C., Zorrilla-Vaca, A., Munoz-Rodes, J. L., Galan-Menendez, P., Mesquida, J., Garcia-Fernandez, J.   +31 more
core   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

A Swan Song: Advances in Hemodynamic Monitoring

, 2019
Objectives Review the history, applications, and limitations of pulmonary artery catheters Provide an overview of new hemodynamic monitoring technologies and their ...
Latona, MD, Jessica
core   +1 more source

Monitoring and Management of Tissue Perfusion After Cardiopulmonary Bypass [PDF]

Zagazig University Medical Journal
Background: Management of tissue perfusion after cardiopulmonary bypass is one of the most critical challenges for anesthesiologists and intensivists.
Mostafa Mostafa, Abeer Elnakera, Amal Salah, Tarek Gaafar   +3 more
doaj   +1 more source

Hemodynamic monitoring in the intensive care unit

, 2003
Hemodynamic monitoring is a diagnostic tool. Because hemodynamic monitoring often requires invasive procedures, it can be associated with an increased incidence of untoward events.
Pinsky, Michael R
core   +1 more source