Results 61 to 70 of about 95,640 (249)

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output

Intensive Care Medicine Experimental, 2019
Background Positive pressure ventilation can decrease venous return and cardiac output. It is not known if expiratory ventilation assistance (EVA) through a small endotracheal tube can improve venous return and cardiac output. Results In a porcine model,
David A. Berlin, Seth Manoach, Clara Oromendia, Paul M. Heerdt   +3 more
doaj   +1 more source

Aging and the Spectral Properties of Brain Hemodynamics

Advanced Science, EarlyView.
As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park, Abraham Z. Snyder, Manu S. Goyal, Timothy O. Laumann, John J. Lee, Babatunde Adeyemo, Nicholas Metcalf, Andrei G. Vlassenko, Joshua S. Shimony, Eric C. Leuthardt   +9 more
wiley   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Tirofiban prevents the effects of SARS-CoV-2 spike protein on macrophage activation and endothelial cell death

Heliyon
SARS-CoV-2 viral-derived particles have been proposed to have a causal role in tissue inflammation. Macrophage is the culprit cell in the pathogenesis of destructive inflammatory response to the SARS-CoV-2 virus. We investigated whether the spike protein
Laura Marrone, Simona Romano, Michele Albanese, Salvatore Giordano, Alberto Morello, Michele Cimmino, Valeria Di Giacomo, Chiara Malasomma, Maria Fiammetta Romano, Nicola Corcione   +9 more
doaj   +1 more source

Comprehensive Insights into Tracheoesophageal Fistula Pathophysiology, Diagnosis, Treatment, and Future Directions

Advanced Science, EarlyView.
Tracheoesophageal fistula (TEF), a pathological trachea‐esophagus connection, arises congenitally or from malignancy/radiotherapy/trauma, causing aspiration and malnutrition. Diagnosis utilizes imaging and endoscopy. Treatment ranges from endoscopic stenting to surgical repair and conservative management.
Gang Li, Zhe Wang, Jia Liu, Shenbo Fu, Longmei Xue, Zijun Liao, Rong Yang, Shanping Huang, Rui Xu, Peng Chen, Yong Chen   +10 more
wiley   +1 more source

AGING AS A FACTOR IN THE RENAL HEMODYNAMIC CHANGES INDUCED BY A STANDARDIZED PYROGEN [PDF]

, 1951
Roger K. McDonald, David H. Solomon, N. W. Shock   +2 more
openalex   +1 more source

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

Advanced Science, EarlyView.
This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker   +17 more
wiley   +1 more source

Study of the Hemodynamic Effects of the Aorto-Coronary Sinus Graft Operation in Patients with Coronary Artery Disease [PDF]

, 1957
THOMAS W. MOIR, W. H. Pritchard
openalex   +1 more source

The role and mechanism of vascular wall cell ion channels in vascular fibrosis remodeling

Channels
Fibrosis is usually the final pathological state of many chronic inflammatory diseases and may lead to organ malfunction. Excessive deposition of extracellular matrix (ECM) molecules is a characteristic of most fibrotic tissues.
Xiaolin Zhang, Hai Tian, Cheng Xie, Yan Yang, Pengyun Li, Jun Cheng   +5 more
doaj   +1 more source