Results 181 to 190 of about 1,783,252 (315)

Elevated Hemoglobin Levels and Risk of ST‐Segment Elevation Myocardial Infarction in High‐Altitude Acute Coronary Syndrome: A Retrospective Analysis

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background High‐altitude populations typically exhibit elevated hemoglobin (Hb) levels due to chronic hypoxic exposure; however, the impact of this elevation on the risk of ST‐segment elevation myocardial infarction (STEMI) remains unclear. Existing evidence is primarily derived from low‐altitude populations and cannot be directly extrapolated
Jing Li, Lin‐Feng Liu, Gusang Lamu, Yang Jin, Gesang Gawa, Zhen‐Long Chang, Xiao‐Xia Liu, Zhen‐Zhong Yang, Gesang Luobu, Baima Lamu, Dawa Ciren   +10 more
wiley   +1 more source

Changes in body composition and their association with erythrocyte mass in regular exercisers: A cross-sectional study. [PDF]

Medicine (Baltimore)
Demircioğlu S, Tekinalp A, Korkmaz C, Alkan Baylan F, Merter M.   +4 more
europepmc   +1 more source

Hemoglobin Variants in Patients With Microcytic Hypochromic Anemia: A Review of Indian Studies. [PDF]

Cureus, 2023
Kharche K, Bhake A.
europepmc   +1 more source

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, EarlyView.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

Haemoglobin variants in nigeria: real-world data from a point-of-care device. [PDF]

Ann Hematol
Kotila T, Aworanti O, Akunwata C, Ogundeji P, Oresanya S, Adewale A, Alabi R, Fasola F, Olaniyi J.   +8 more
europepmc   +1 more source

Drug Repositioning of Pegbing® for Essential Thrombocythemia: Insights from PK/PD Modeling and Extrapolation

Clinical Pharmacology &Therapeutics, EarlyView.
Pegbing® (peginterferon alfa‐2b), a pegylated interferon‐alpha, is approved for the treatment of chronic hepatitis B (CHB) and C. One of its adverse effects is platelet (PLT) suppression. It is currently being repurposed for the treatment of essential thrombocythemia (ET), a rare myeloproliferative disorder characterized by abnormally elevated PLT ...
Weizhe Jian, Yalin Yin, Rong Chen, Junsheng Xue, Jianbo Gu, Zhengfang Du, Ruoyi He, Tianyan Zhou   +7 more
wiley   +1 more source

[Abnormal hemoglobins].

Revista espanola de pediatria, 1998
J, de ARAUJO, M, JAMRA
  +6 more sources

Clinical and hematological characteristics of beta-plus thalassemia and uncommon beta-chain hemoglobin variants in Northern Thailand. [PDF]

Ann Med
Rukwong P, Natesirinilkul R, Sathitsamitphong L, Choed-Amphai C, Tantiworawit A, Fanhchaksai K, Maneekesorn S, Charoenkwan P.   +7 more
europepmc   +1 more source

Studies on abnormal hemoglobins. VI. Electrophoretic demonstration of type S (sickle cell) hemoglobin in erythrocytes incapable of showing the sickle cell phenomenon.

Blood, 1953
K. Singer, B. Fisher
semanticscholar   +1 more source

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen, Menno van Diemen, Liza Botros, Ingrid Tomljanovic, Hind Achbo, Dimitra Eleftheriou, Paul Willem Schenk, Naomi Bertine Klarenbeek, Derek William Gilroy, Manon Aleida Adriana Jansen, Matthijs Moerland   +10 more
wiley   +1 more source