Results 311 to 320 of about 216,432 (383)

Case report: Metformin-induced hemolytic anemia in a glucose-6-phosphate dehydrogenase-deficient patient. [PDF]

J Int Med Res
Salamat AM, Ammar HM, Alsagheir AI, Mushcab HS.   +3 more
europepmc   +1 more source

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

<i>In vitro</i> investigation of elevated hemolysis susceptibility in neonatal blood. [PDF]

Front Pediatr
Heyer J, Volmering S, Hoyos-Banchon C, Koc S, Jeremiah L, Steinseifer U, Orlikowsky T, Jansen SV, Clauser JC, Schoberer M.   +9 more
europepmc   +1 more source

Fimbriae‐Targeted Peptide‐Selenoviologen Cyclophane Complex for Enhanced Photodynamic Therapy of Periodontitis

Aggregate, EarlyView.
This study develops a supramolecular photosensitizer (SeVB⊃PQ) by combining SeVB with a P. gingivalis‐targeting peptide. SeVB⊃PQ selectively binds P. gingivalis, boosts ROS generation under irradiation, disrupts ATP synthesis, restores microbial balance, reduces inflammation, and promotes alveolar bone regeneration, offering a promising platform for ...
Rui Ding, Yawen Li, Yuchen Zhang, Qi Sun, Ang Li, Kun Zhou, Dandan Pei, Gang He   +7 more
wiley   +1 more source

Chronic kidney disease following left ventricular assist device implantation: contemporary insights and future perspectives. [PDF]

Heart Fail Rev
Alvarez-Echeverry I, Guven G, Jahangiri P, Hesselink DA, Soliman O, Rajapreyar I, Rame JE, Ince C, Caliskan K.   +8 more
europepmc   +1 more source

Overcoming Clinical Barriers: Utilizing Self‐Assembly Systems to Break the Protease Limitations of Antimicrobial Peptides

Aggregate, EarlyView.
This study addresses AMPs' clinical application challenges by enhancing stability via molecular assembly. Pba* shows high antibacterial activity, biocompatibility, and low toxicity, paving the way for antimicrobial materials. ABSTRACT Natural antimicrobial peptides (AMPs) encounter significant challenges in transitioning to clinical application ...
Xu Guo, Weikang Yu, Qingrui Li, Xuefeng Li, Yingxin Wei, Jiajun Wang, Yinfeng Lyu, Anshan Shan   +7 more
wiley   +1 more source

Iptacopan for cold agglutinin disease: a case report with literature review. [PDF]

Front Immunol
Fang B, Lu H, Yu X, Wang P, Zhou Y, Shen Q, Yuan M, Lyu M, He G.   +8 more
europepmc   +1 more source

Aggregation‐Enhanced Asymmetric Heptamethine Cyanine Nanoplatform for Imaging‐Guided Synergistic Phototherapy and Ferroptosis

Aggregate, EarlyView.
An asymmetric heptamethine cyanine photosensitizer, Cyp‐TPE, is designed to break molecular symmetry and form ordered nanoaggregates, resulting in ultrahigh ROS generation and synergistic photothermal/photodynamic activity. It further triggers ferroptosis and lysosomal dysfunction, providing a potent aggregate‐based theranostic platform for imaging ...
Mengyuan Cui, Wenqing Li, Yanli Chen, Huijia Liu, Li Liu, Min Ji, Peng Wang   +6 more
wiley   +1 more source

Intravascular Hemolysis and Acute Kidney Injury Following an Emergent Cesarean Delivery: A Case Report. [PDF]

Cureus
Nalla SD, Chopra S, Rama S, Lambroussis CG.   +3 more
europepmc   +1 more source