Results 111 to 120 of about 9,064,819 (381)

DomainScope: A disease network based on protein domain connections [PDF]

arXiv, 2019
Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv  

Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?

Journal of the American Society of Nephrology, 2014
Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated with overactivation of the alternative pathway of complement.
M. Marinozzi, L. Vergoz, T. Rybkine, S. Ngo, Serena Bettoni, A. Pashov, M. Cayla, Fanny Tabarin, M. Jablonski, C. Hue, Richard J. H. Smith, M. Noris, L. Halbwachs‐Mecarelli, R. Donadelli, V. Frémeaux-Bacchi, L. Roumenina   +15 more
semanticscholar   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

Hereditary hemochromatosis associated with autoimmune hemolytic anemia; A case report [PDF]

Journal of Preventive Epidemiology, 2019
Hereditary hemochromatosis is a disease associated with highly iron overload. This disease caused by genetic mutations inherited through family. Autoimmune hemolytic anemia is also an important autoimmune disease in which red blood cells (RBC) are ...
Masih Falahatian, Mohammad Reza Khosravi Farsani, Ali Hajigholami   +2 more
doaj  

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

An Off‐the‐Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment

Advanced Science, EarlyView.
Artificial macrophages (artM) by encapsulating M2 lysates into biodegradable PLGA microspheres and coated with macrophage membrane, are engineered as new therapeutics against skin pressure ulcer. In mouse models, the artM exhibited robust tissue repair through cell recruitment and microenvironment modulation, showing great therapeutic potential for ...
Qi Su, Jingrong Wang, Yini Huangfu, Rui Gao, Pengxu Kong, Yu Gao, Huijuan Song, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Zujian Feng, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

HEMOLYTIC DISEASE OF THE NEWBORN

Jurnal Kedokteran Syiah Kuala, 2018
Abstrak. Pemahaman penyakit hemolitik pada bayi baru lahir telah berubah selama beberapa dekade terakhir. Penyakit hemolitik akibat inkompatibilitas ABO dan aloantibodi lainnya kini muncul sebagai penyebab utama. Banyak negara telah mengidentifikasi aloantibodi selain anti D sebagai penyebab penyakit hemolitik dengan gejala klinis sedang sampai dengan ...
openaire   +2 more sources

Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury

Advanced Science, EarlyView.
A biomimetic MOF nanocarrier for macrophage‐targeting delivery of both mitochondria and anti‐miR‐127 is designed with an aim to revitalize macrophages and remold the inflammatory microenvironment for treating acute lung injury. By leveraging the macrophages‐targeting property and pH‐responsiveness, ZIF‐8 nanocarriers facilitated efficient delivery of ...
Xin Shou, Changjiang Chen, Hangjie Ying, Zhiyun Liu, Lingyao Zeng, Qiujie Li, Lanjie Lei, Bingyong Mao, Wei Zhang, Shumao Cui, Liyun Shi   +10 more
wiley   +1 more source

Time series analysis of Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis [PDF]

arXiv, 2013
The aim of this paper is to study the (clinical) time-series data of three diseases with complex dynamics: Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis. For this purpose, first all of the time series data are embedded in a vector space of suitable dimension and then the correlation dimension of the above mentioned ...
arxiv  

STUDIES ON PRIMARY ATYPICAL PNEUMONIA. II. OBSERVATIONS CONCERNING THE RELATIONSHIP OF A NON-HEMOLYTIC STREPTOCOCCUS TO THE DISEASE 12 [PDF]

, 1945
Lewis Thomas, George S. Mirick, Edward C. Curnen, James E. Ziegler, Frank L. Horsfall   +4 more
openalex   +1 more source