Results 241 to 250 of about 1,327,207 (407)

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni   +12 more
wiley   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

open access: yesAdvanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu   +16 more
wiley   +1 more source

A 3D Printing Strategy for Hard Curved Surfaced Circuits: From Materials to Applications

open access: yesAdvanced Science, EarlyView.
Conventional PCB etching (multi‐step) and indirect transfer techniques fail to meet structural electronics’ demands for lightweight, miniaturized, and customized manufacturing. 3D‐printed conformal circuits enable direct integration of conductive traces into substrates or onto surfaces, achieving integrated structural‐functional fabrication.
Wang Qin   +12 more
wiley   +1 more source

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