Results 91 to 100 of about 1,399,338 (302)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

open access: yesAdvanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang   +11 more
wiley   +1 more source

Relationship between transmission intensity and incidence of dengue hemorrhagic fever in Thailand. [PDF]

open access: yes, 2008
BACKGROUND: Dengue is the most prevalent mosquito-borne virus, and potentially fatal dengue hemorrhagic fever (DHF) occurs mainly in secondary infections.
Coleman Paul G.   +24 more
core   +2 more sources

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

open access: yesAdvanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao   +7 more
wiley   +1 more source

Vitamin K-dependent coagulopathy in neonatological and pediatric practice: controversial issues and clinical analysis [PDF]

open access: yesРМЖ. Мать и дитя
A.L. Zaplatnikov1,2, A.V. Dmitriev1,3, B.D. Babaev1, A.A. Dement'ev1, Zh.L. Chabaidze1, I.D. Maikova2, M.V. Leshik1, D.N. Smirnov1 1Russian Medical Academy of Continuous Professional Education, Moscow,   Russian Federation 2Z.A ...
A.L. Zaplatnikov   +7 more
doaj  

A rare case of post-operative bleeding in cataract surgery – An eye opener

open access: yesIndian Journal of Ophthalmology. Case Reports
Ocular surgery in patients with bleeding disorders is challenging due to the high risk of hemorrhagic complications. This case report of a patient with chronic decompensated liver disease, who presented with incessant postoperative bleeding, served as a ...
Meera B Rahim   +5 more
doaj   +1 more source

Poor housing quality increases risk of rodent infestation and lassa fever in refugee camps of Sierra Leone [PDF]

open access: yes, 2007
Lassa fever, a viral hemorrhagic fever endemic in parts of West Africa, is a severe febrile illness transmitted to humans by the rodent Mastomys natalensis. To determine risk of Lassa fever in households in Sierra Leonean refugee camps, we analyzed the
Wolf-Peter Schmidt   +13 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

open access: yes
Arthritis Care &Research, EarlyView.
Catherine Deffendall   +6 more
wiley   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

open access: yesAdvanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao   +7 more
wiley   +1 more source

Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007 [PDF]

open access: yes, 2011
Marburg hemorrhagic fever was detected among 4 miners in Ibanda District, Uganda, from June through September, 2007. Infection was likely acquired through exposure to bats or bat secretions in a mine in Kamwenge District, Uganda, and possibly human-to ...
Wamala, Joseph F   +39 more
core   +1 more source

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