Results 131 to 140 of about 39,655 (319)

The Second Mitochondria‐Derived Activator of Caspases Mimetic BI 891065 in Patients With Advanced Solid Tumors: Results From Two Phase I Studies

Cancer Medicine, Volume 14, Issue 24, December 2025.
ABSTRACT Introduction BI 891065, a second mitochondria‐derived activator of caspases mimetic targets the inhibitor of apoptosis (IAP) family member cIAP1. We describe two first‐in‐human phase 1 trials assessing BI 891065 ± the anti‐programmed cell death protein‐1 (PD1) antibody, ezabenlimab, in advanced solid tumors.
Manish R. Patel, Erika P. Hamilton, Ben George, Gunther Kretschmar, Akiko Harada, Ralph Graeser, Anastasia Eleftheraki, Yoshifumi Tachibana, Noboru Yamamoto   +8 more
wiley   +1 more source

Effects of Intravenous Administration of Vancomycin on Peritonitis in a Patient on Peritoneal Dialysis

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT In settings where intraperitoneal vancomycin is unavailable or off‐label (e.g., Japan), intravenous vancomycin can be a viable treatment option for peritoneal dialysis‐associated peritonitis. Due to limited pharmacokinetic data regarding intravenous dosing, pragmatic strategies involving more frequent therapeutic drug monitoring—measuring both
Natsuri Yonezawa, Ayako Watanabe, Tatsuki Iha, Akari Ito, Akari Koizumi, Nana Kikuchi, Hiromi Koshizuka, Yuka Kashiwabara, Akiko Takeshima, Tomoaki Miyazaki, Kei Matsumoto, Kenji Momo   +11 more
wiley   +1 more source

Hemorrhagic Fever with Renal Syndrome

Infection and Chemotherapy, 2009
Hemorrhagic fever with renal syndrome (HFRS) is an acute febrile illness caused by Eurasian hantaviruses and characterized by renal insufficiency, hemorrhage, thrombocytopenia, and shock. Each hantavirus is primarily associated with a single rodent host species or genus, and is transmitted to human via aerosols of rodent excreta.
openaire   +1 more source

Triple Vessel Disease With Intracranial Hemorrhage in a Patient With Guillain–Barre Syndrome: A Potential Complication, a Coincidental Finding or a Treatment‐Related Adverse Event

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Triple vessel disease and intracranial hemorrhage complicating Guillain–Barre syndrome have been rarely reported. Furthermore, there are no established theories that explain the pathophysiological association between these three different clinical scenarios.
Sagun Ghimire, Shikher Shrestha, Dinuj Shrestha, Ananta Maharjan, Kritick Bhandari, Suman Bhattarai, Kajan Ranabhat   +6 more
wiley   +1 more source

Pulmonary involvement in hemorrhagic fever with renal syndrome

International Journal of Infectious Diseases
Introduction: Hemorrhagic fever with renal syndrome (HFRS) has recently begun to change its clinical features. Involving the lungs in the inflammatory process started to be recorded not only in rare cases of severe disease but also in patients with a ...
Professor Vera Pavelkina, PhD Rimma Almiasheva, Prof Natalia Pshenichnaya   +2 more
doaj   +1 more source

ASSESMENT OF IL–12 ACTIVITY IN PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME ASSOCIATED WITH SEOUL SEROTYPE

Медицинская иммунология, 2014
. Immunopathological mechanisms of hemorrhagic fever with renal syndrome (HFRS) are very complex and are recognized as the cause of the basic pathophysiological abnormalities in this infection.
L. Yu. Pereverten, E. V. Markelova
doaj   +1 more source

Chronic Renal Dysfunction in Hemorrhagic Fever with Renal Syndrome Patients

Renal Failure, 1993
During the last 9 years, 32 cases of hemorrhagic fever with renal syndrome (HFRS) have been diagnosed in our institution. Seven patients died. Twenty-three patients were discharged healthy while in another 2 some degree of renal dysfunction, which remained stable 12-15 months later, was evident.
Elisaf, M. S., Korakis, H., Siamopoulos, K. C.   +2 more
openaire   +3 more sources

A Phase 2a Randomized, Double-Blind, Dose-Optimizing Study to Evaluate the Immunogenicity and Safety of a Bivalent DNA Vaccine for Hemorrhagic Fever with Renal Syndrome Delivered by Intramuscular Electroporation [PDF]

, 2020
Jay W. Hooper, Kristopher Paolino, Kristin T Mills, Steve Kwilas, Matthew Josleyn, Melanie Cohen, Brandon Somerville, Marcin Wiśniewski, Sarah L. Norris, Brenna J. Hill, Mariano Sánchez-Lockhart, D. Hannaman, Connie S. Schmaljohn   +12 more
openalex   +1 more source

Advanced Wilms Tumor in a Middle‐Aged Adult: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Wilms tumor, or nephroblastoma, is a malignant embryonal tumor originating from nephrogenic blastema, which imitates the histology of a developing kidney. Primarily, it occurs in children. Wilms tumor is exceedingly rare in adults, where the diagnosis is often delayed, and the prognosis tends to be worse compared to children.
Denis Mucunguzi, Bartholomeo Nicholaus Ngowi, Orgeness Jasper Mbwambo, Phinihas Jackson Mwijumbe, Nyamhanga Nsaho Maro, Abitalis Mayengela, Angumbwike Mwakitwange, Patrick Amsi, Donald Dominick Lema, Alex Mremi   +9 more
wiley   +1 more source

Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome [PDF]

, 2017
Svetlana F. Khaiboullina, Silvana Levis, Sergey P. Morzunov, Ekaterina Martynova, В. А. Анохин, Oleg Gusev, Stephen C. St. Jeor, Vincent C. Lombardi, Albert A. Rizvanov   +8 more
openalex   +1 more source