Results 281 to 290 of about 3,221,536 (372)

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

open access: yesSmall, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai   +5 more
wiley   +1 more source

A mitochondria‐targeted aggregation‐induced emission photosensitizer for eradication Candida biofilms and treating oral ulcer

open access: yesSmart Molecules, EarlyView.
A mitochondria‐targeted AIE photosensitizer, LIQ‐TPA‐TZ, was developed to fight against Candida infection. It can efficiently produce reactive oxygen species to kill Candida guilliermondii and eradicate biofilms. It not only disrupted the respiratory chain and affected the metabolism and energy supply but also reduced the fungi adhesion and filament ...
Kun‐Mei Liu   +5 more
wiley   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

open access: yesSmall Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli   +6 more
wiley   +1 more source

Conductive Hydrogel‐Based Neural Interfaces: From Fabrication Methods, Properties, to Applications

open access: yesSmall Structures, EarlyView.
This review summarizes the fabrication methods, properties, and applications of conductive hydrogels in neural interfaces. Finally, the prevailing challenges and outlines of future directions in the field of conductive hydrogels for neural interfaces are provided, emphasizing the need for interdisciplinary research to address issues such as long‐term ...
Xin‐Yu Xue   +10 more
wiley   +1 more source

A Smart Functional Microneedle, Tethered with Neuropeptide S and Tissue Inhibitor of Metalloproteinases, Promotes Skin, Vascular, and Nerve Regeneration for Chronic Diabetic Skin Wound Healing

open access: yesSmall Structures, EarlyView.
A smart functional microneedle system, tethered with NPS and TIMP, which not only promotes diabetic wound healing and tissue remodeling at the injury site but also demonstrates the ability to dynamically and responsively release NPS and TIMP as needed, offering a potential therapeutic approach for clinical translation is presented. Increased expression
Yan Gao   +5 more
wiley   +1 more source

Novel Surgical Strategy System for Juvenile Nasopharyngeal Angiofibroma: A Focus on Feeding Artery Management

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives For intraoperative bleeding control in patients with juvenile nasopharyngeal angiofibroma (JNA), we developed a novel surgical strategy system. This system is focused on feeding artery management, based on the spatial relationship between the tumor entity and feeding artery as determined by three‐dimensional reconstruction.
Nian‐Zhen Zheng   +10 more
wiley   +1 more source

Design of a Consensus Derived Synoptic Operative Report for Thyroid Surgery

open access: yesWorld Journal of Surgery, EarlyView.
The aim of this study was to develop a template for a synoptic operative report (SOR), for thyroid surgical data, and improve interdisciplinary communication and collaboration. Twenty‐five expert endocrine surgeons, endocrinologists, surgical oncology, and ear‐nose‐and‐throat surgeons were invited to participate in a modified Delphi process.
Edwina C. Moore   +7 more
wiley   +1 more source

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