Results 11 to 20 of about 136,859 (221)

Phylogenomic Analyses of Hepatica Species and Comparative Analyses Within Tribe Anemoneae (Ranunculaceae)

Frontiers in Plant Science, 2021
Hepatica is a small genus of Ranunculaceae with medicinal and horticultural value. We characterized nine complete chloroplast (cp) genomes of Hepatica, which ranged from 159,549 to 161,081 bp in length and had a typical quadripartite structure with a ...
Kyu Tae Park, SeonJoo Park
doaj   +2 more sources

A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance

PLoS Pathogens, 2023
Fasciola hepatica infection is responsible for substantial economic losses in livestock worldwide and poses a threat to human health in endemic areas. The mainstay of control in livestock and the only drug licenced for use in humans is triclabendazole ...
N. Beesley, Krystyna Cwiklinski, K. Allen, Rebecca C Hoyle, T. Spithill, E. James, La Course, Diana J. L. Williams, S. Paterson, J. Hodgkinson   +9 more
semanticscholar   +1 more source

Extracellular vesicles from the trematodes Fasciola hepatica and Dicrocoelium dendriticum trigger different responses in human THP‐1 macrophages

Journal of Extracellular Vesicles, 2023
Extracellular vesicles (EVs) released by the helminths Dicrocoelium dendriticum and Fasciola hepatica are important modulators of the host immune response, contributing to the establishment of the infection.
Christian M. Sánchez-López, Aránzazu Gónzalez-Arce, C. Soler, Víctor Ramírez-Toledo, M. Trelis, D. Bernal, A. Marcilla   +6 more
semanticscholar   +1 more source

Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

Virulence, 2021
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the most important neglected parasitic diseases of humans and animals.
R. Lalor, Krystyna Cwiklinski, N. Calvani, A. Dorey, S. Hamon, Jesús López Corrales, J. Dalton, C. De Marco Verissimo   +7 more
semanticscholar   +1 more source

Paleobiogeographical origins of Fasciola hepatica and F. gigantica in light of new DNA sequence characteristics of F. nyanzae from hippopotamus

Frontiers in Veterinary Science, 2022
Fascioliasis is a highly pathogenic disease affecting humans and livestock worldwide. It is caused by the liver flukes Fasciola hepatica transmitted by Galba/Fossaria lymnaeid snails in Europe, Asia, Africa, the Americas and Oceania, and F.
M. Bargues, A. Halajian, P. Artigas, W. Luus‐Powell, M. Valero, S. Mas‐Coma   +5 more
semanticscholar   +1 more source

Targeting Secreted Protease/Anti-Protease Balance as a Vaccine Strategy against the Helminth Fasciola hepatica

Vaccines, 2022
The liver fluke Fasciola hepatica is an economically important global pathogen of humans and their livestock. To facilitate host invasion and migration, F.
Krystyna Cwiklinski, Orla Drysdale, Jesús López Corrales, Y. Corripio-Miyar, C. De Marco Verissimo, H. Jewhurst, David Smith, R. Lalor, T. McNeilly, J. Dalton   +9 more
semanticscholar   +1 more source

Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver

BMC Genomics, 2021
The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and development in the liver.
Krystyna Cwiklinski, M. Robinson, S. Donnelly, J. Dalton   +3 more
semanticscholar   +1 more source

Developmental Regulation and Functional Prediction of microRNAs in an Expanded Fasciola hepatica miRNome

bioRxiv, 2021
The liver fluke, Fasciola hepatica, is a global burden on the wellbeing and productivity of farmed ruminants, and a zoonotic threat to human health. Despite the clear need for accelerated discovery of new drug and vaccine treatments for this pathogen, we
Caoimhe M. Herron, A. O’Connor, Emily Robb, Erin McCammick, Claire Hill, N. Marks, M. Robinson, A. Maule, P. McVeigh   +8 more
semanticscholar   +1 more source

Fasciola hepatica-Derived Molecules as Regulators of the Host Immune Response

Frontiers in Immunology, 2020
Helminths (worms) are one of the most successful organisms in nature given their ability to infect millions of humans and animals worldwide. Their success can be attributed to their ability to modulate the host immune response for their own benefit by ...
S. Ryan, J. Shiels, C. Taggart, J. Dalton, S. Weldon   +4 more
semanticscholar   +1 more source

Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases

PLoS Neglected Tropical Diseases, 2020
Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica excretory-secretory products indicates
C. De Marco Verissimo, H. Jewhurst, I. Tikhonova, R. Urbanus, A. Maule, J. Dalton, Krystyna Cwiklinski   +6 more
semanticscholar   +1 more source