Results 51 to 60 of about 96,473 (194)

A Self-Tuning Solution of the Cosmological Constant Problem [PDF]

, 2000
We discuss the four-dimensional cosmological constant problem in a five-dimensional setting. A scalar field coupled to the SM forms dynamically a smooth brane with four-dimensional Poincare invariance, independently of SM physics.
A. KEHAGIAS, K. TAMVAKIS, Kachru S.
core   +2 more sources

Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the pleiotropic response to resveratrol and berberine

Advances in Medical Sciences, 2022
Human carcinoma cells with different p53 status exposed to a combination of bioactive substances, resveratrol and berberine, revealed different responses in cell viability via p53-dependant apoptosis pathway activation.Using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay, we investigated various and
Magdalena Skonieczna, Malgorzata Adamiec-Organisciok, Dorota Hudy, Arkadiusz Dziedzic, Laura Los, Lubomir Skladany, Ivica Grgurevic, Tajana Filipec-Kanizaj, Miczyslaw Jagodzinski, Michal Kukla, Joanna Nackiewicz   +10 more
openaire   +3 more sources

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

Biodegradable Adhesive Systems for Bio‐Integrated Applications

Advanced Science, EarlyView.
Biodegradable adhesives provide temporary yet reliable adhesion while degrading into safe, non‐toxic by‐products under physiological or environmental conditions. This review summarizes recent developments in physical and chemical adhesion mechanisms—including hydrogen bonding, catechol chemistry, amine‐carboxyl coupling, and emerging diazirine and urea
Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li‐Hyun Kim, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +6 more
wiley   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Freezing Characteristics of Isolated Pig and Human Hepatocytes

Cell Transplantation, 1997
The cellular response of isolated hepatocytes from pigs, humans, and human hepatoblastoma cells to freezing was characterized using cryomicroscopy and analyzed using a thermodynamic model for water transport and Intracellular Ice Formation (IIF).
T.B. Darr, A. Hubel
doaj   +1 more source

Wilson Loops in N=2 Superconformal Yang-Mills Theory [PDF]

, 2010
We present a three-loop O(g^6) calculation of the difference between the expectation values of Wilson loops evaluated in N=4 and superconformal N=2 supersymmetric Yang-Mills theory with gauge group SU(N) using dimensional reduction.
Andree, Roman, Young, Donovan
core   +2 more sources

Secretion of proalbumin by canavanine-treated Hep-G2 cells.

Journal of Biological Chemistry, 1983
The two processing sites in the conversion of preproalbumin to albumin are marked by arginine residues. Therefore, to study the mechanisms of albumin processing and secretion, the arginine residues of nascent albumin were replaced with canavanine by the incubation of Hep-G2 cells with this arginine analog.
C M, Redman, G, Avellino, S, Yu
openaire   +2 more sources

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

An ${\cal N}=3$ Solution in Dyonic ISO(7) Gauged Maximal Supergravity and Its Uplift to Massive Type IIA

, 2015
We consider a certain ${\cal N}=1$ supersymmetric, SO(3)$\times$SO(3) invariant, subsector of the dyonic ISO(7)-gauged maximal supergravity in four-dimensions. The theory contains two scalar fields and two pseudoscalar fields.
Pang, Yi, Rong, Junchen
core   +1 more source