Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice [PDF]
, 2017 Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met ...
Anthony, Tracy G. +11 more
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HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse
Scientific Reports, 2020 Excessive intake of fat causes accumulation of fat in liver, leading to non-alcoholic fatty liver disease (NAFLD). High-fat diet (HFD) upregulates the expression of Factor D, a complement pathway component, in the liver of mice. However, the functions of
Hiromi Tsuru +3 more
doaj +1 more source
Pharmacologic modulation of experimental postischemic hepatic function [PDF]
, 1989 The present study, evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 ...
Makowka, L +5 more
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The Professional Medical Journal, 2018 Background: Infections with Hepatitis B Virus (HBV) and Hepatitis C virus (HCV) are worldwide public health problem. Thisis related to the continued occurrence of new infections and the presence of a large reservoir of chronically infected persons. Objective:To determine the frequency of risk factors (causes of transmission) for HBV and HCV infections ...
MUHAMMAD ASHRAF CHAUDHRY +4 more
openaire +2 more sources
Hepatic resection for metastatic colorectal adenocarcinoma: A proposal of a prognostic scoring system [PDF]
, 1999 Background: Hepatic resection for metastatic colorectal cancer provides excellent longterm results in a substantial proportion of patients. Although various prognostic risk factors have been identified, there has been no dependable staging or prognostic ...
Bonham, AC +9 more
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Induced maturation of hepatic progenitor cells in vitro
Brazilian Journal of Medical and Biological Research, 2013 Hepatic progenitor cells (HPCs) are a potential cell source for liver cell transplantation but do not function like mature liver cells. We sought an effective and reliable method to induce HPC maturation.
Y. Bi +6 more
doaj +1 more source
Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells
Stem Cells International, 2019 We previously described the generation of induced hepatocyte-like cells (iHeps) using the hepatic transcription factor Hnf1a together with small molecules.
Seon In Hwang +8 more
doaj +1 more source
Stem Cell Research & Therapy, 2017 Background Although they are expandable in vitro, hepatic progenitors are immature cells and share many immunomarkers with hepatocellular carcinoma, raising potential concerns regarding maltransformation after transplantation. This study investigated the
Ping Wang +13 more
doaj +1 more source
Extra-hepatic factor VIII expression in porcine fulminant hepatic failure [PDF]
Journal of Thrombosis and Haemostasis, 2005 In humans, fulminant hepatic failure (FHF) is frequently associated with increased factor VIII (FVIII) levels, despite widespread liver cell death. The mechanisms leading to increased FVIII levels and cellular sites of this enhanced FVIII production are poorly understood.
Hollestelle, M. J. +5 more
openaire +3 more sources
Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]
, 2012 BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen +5 more
core +2 more sources