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Medicina Clínica (English Edition), 2018
Chronic liver diseases constitute a major health problem. Chronic liver inflammation, defined by the degree of hepatic fibrosis, is asymptomatic in a significant percentage of patients; hence, the disease often remains undiagnosed until it has reached very advanced phases and, frequently, when the damage is irreversible.
Llorenç, Caballería +2 more
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Chronic liver diseases constitute a major health problem. Chronic liver inflammation, defined by the degree of hepatic fibrosis, is asymptomatic in a significant percentage of patients; hence, the disease often remains undiagnosed until it has reached very advanced phases and, frequently, when the damage is irreversible.
Llorenç, Caballería +2 more
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Isoprostanes and hepatic fibrosis
Molecular Aspects of Medicine, 2008After a brief introduction to oxidative stress, the discovery of F(2)-isoprostanes as specific and reliable markers of oxidative stress is described. Isoprostanes are also agonists of important biological effects. Since a relation between oxidative stress and collagen hyperproduction has been previously suggested and since lipid peroxidation products ...
COMPORTI, M. +5 more
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The American Journal of Digestive Diseases, 1974
Congenital hepatic fibrosis (CHF) was detected in a 10-year-old boy with hepatosplenomegaly and leukopenia and in a 45-year-old man with hepatomegaly. Several years after these original findings, both patients developed bleeding that was attributed to esophageal varices and were treated by elective portasystemic shunts.
H A, Campana, Y S, Park, G D, Gourgoutis
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Congenital hepatic fibrosis (CHF) was detected in a 10-year-old boy with hepatosplenomegaly and leukopenia and in a 45-year-old man with hepatomegaly. Several years after these original findings, both patients developed bleeding that was attributed to esophageal varices and were treated by elective portasystemic shunts.
H A, Campana, Y S, Park, G D, Gourgoutis
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Journal of Pediatric Gastroenterology and Nutrition, 1984
One family with four of seven siblings with congenital hepatic fibrosis. is reported. The proband, the only member of this family with symptoms referable to the disease, was hospitalized because of an upper gastrointestinal hemorrhage. He had a presinusoidal type of portal hypertension. The other three siblings had the latent form of congenital hepatic
J, Pereira-Lima +3 more
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One family with four of seven siblings with congenital hepatic fibrosis. is reported. The proband, the only member of this family with symptoms referable to the disease, was hospitalized because of an upper gastrointestinal hemorrhage. He had a presinusoidal type of portal hypertension. The other three siblings had the latent form of congenital hepatic
J, Pereira-Lima +3 more
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Reversibility of Hepatic Fibrosis in Autoimmune Hepatitis
Annals of Internal Medicine, 1997Hepatic fibrosis and cirrhosis occur in many types of chronic liver injury and generally seem to be irreversible.To determine whether cirrhosis caused by autoimmune hepatitis can be reversible.Retrospective study.Eight patients with autoimmune hepatitis and cirrhosis who responded to medical therapy and had follow-up liver biopsy while in clinical and ...
J F, Dufour, R, DeLellis, M M, Kaplan
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Congenital hepatic fibrosis of heterotopic hepatic tissue
Pathology - Research and Practice, 1998We describe a unique case of a one-month-old infant with congenital hepatic fibrosis in the heterotopic liver within the adrenal gland. The main (orthotopic) liver was normal. Complex congenital heart disease and asplenia were associated.
M, Zlatković, S, Duricić, P, Plamenac
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Hepatic Fibrosis: Emerging Therapies
Digestive Diseases, 2015There has been tremendous progress made in understanding the pathogenesis of hepatic fibrosis, which has created new opportunities for the treatment of this condition. Clinical evidence of fibrosis reversibility has established that the liver has the capacity to resorb scar tissue, and future therapies will be based in part on this insight ...
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Hepatic Fibrosis in Hepatitis C
2016Infection with the Hepatitis C virus (HCV) leads to liver inflammation and fibrosis, which progresses to cirrhosis. Cirrhosis leads to complications including hepatocellular carcinoma (HCC), end-stage liver disease, the necessity for liver transplantation, or death. In fact, HCV is the leading cause of liver transplantation, accounting for more than 40
Melissa A. Sheiko, Hugo R. Rosen
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