Results 101 to 110 of about 74,999 (298)

Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats

Animal Models and Experimental Medicine, EarlyView.
DPSCs, hepatocytes, and exosomes were tested for liver fibrosis therapy. Exosome‐based treatment exhibited superior antioxidative and regenerative effects. Liver enzymes, oxidative stress, and profibrotic markers were significantly reduced. α‐SMA, desmin, and related gene expression were downregulated.
Sahar Rahimi, Seyedeh Mahdieh Khoshnazar, Ali Derakhshani, Nader Shahrokhi   +3 more
wiley   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis.

, 1998
Alcoholic liver disease is associated with three histologically distinct processes: steatosis (parenchymal fat accumulation), alcoholic hepatitis (characterized by parenchymal infiltration by neutrophil polymorphs), and alcoholic cirrhosis (in which ...
Fisher, N C, ADAMS DH, Afford, S C, FEAR J, AFFORD SC, Hubscher, S G, HUBSCHER SG, FISHER NC, BRUN, PAOLA, Neil, D A, Brun, P, Adams, David, NEIL DAH, Fear, J   +13 more
core   +1 more source

Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the risk of intrahepatic cholestasis of pregnancy (ICP) in azathioprine (AZA)–exposed versus unexposed systemic lupus erythematosus (SLE) pregnancies within the multicenter prospective Lupus in Pregnancy (LEGACY) cohort. Methods LEGACY is conducted at Systemic Lupus International Collaborating Clinics in Canada, South Korea, Peru,
Reem Farhat, Maria del Carmen Zamora‐Medina, Sang‐Cheol Bae, Megan R. W. Barber, Ann E. Clarke, Paul R. Fortin, Zahi Touma, Carl A. Laskin, Isabelle Malhamé, Giada Sebastiani, Christine Peschken, Manuel F. Ugarte‐Gil, Alexandra Legge, Sasha Bernatsky, Évelyne Vinet   +14 more
wiley   +1 more source

Comparative Study on Serum Enzyme Levels in Cirrhosis of Liver and Alcoholic Liver Disease

Journal of Basic and Applied Research in Biomedicine, 2022
Patients with chronic liver diseases are asymptomatic or have only vague non-specific symptoms. Effective medical treatments for chronic liver disease (before cirrhosis is established) are becoming increasingly available and since abnormal LFTs may be ...
P Rjeshwari, G Obulesu , R Ershad, Salma Mahaboob   +3 more
doaj   +2 more sources

Prednisolone or pentoxifylline for alcoholic hepatitis [PDF]

, 2015
BACKGROUND: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use.
Stanton, L, Vergis, Nikhil, Patch, David, MacGilchrist, A, Steroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH), O’Grady, John, Patch, D, Ratcliffe, Ian, Ryder, S, Austin, Andrew, Austin, A, Grant, A, MacGilchrist, Alastair, Roderick, Paul, Masson, Steven, Gleeson, D, Hood, S, McCune, Anne, Forrest, Ewan H., Thursz, Mark R., Stanton, Louise, Ratcliffe, I, McCune, A, Hood, Steven, Ryder, Stephen, Richardson, P, Masson, S, O'Grady, J, Richardson, Paul, Allison, Michael, Day, Christopher P., Wright, Mark, Thursz, MR, Downs, Nichola, Allison, M, Mellor, J, Day, CP, Vergis, N, Gleeson, Dermot, Mellor, Jane, Grant, Allister, Bowers, M, Wright, M, Bowers, Megan, Roderick, P, Downs, N, Forrest, EH   +46 more
core   +1 more source

Alcoholic hepatitis

, 2023
Alcoholic hepatitis should be suspected in patients with a recent onset of jaundice and with excessive chronic alcohol consumption. Diagnosis is based on clinical presentation and typical laboratory findings (aspartate aminotransférase (AST)/alanine ...
Moreno, Christophe, Degré, Delphine, Deltenre, Pierre   +2 more
core   +1 more source

Patients on statins with elevated transaminases: Frequency of follow‐up creatine kinase testing and gastroenterology referral

British Journal of Clinical Pharmacology, EarlyView.
Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh, Anas Kartoumah, Rajshri Joshi, Anjali Nadihaan, Mohammed Mouchli, Inderprit Singh   +5 more
wiley   +1 more source

Role of liver transplantation in severe alcoholic hepatitis [PDF]

Clinical and Molecular Hepatology, 2018
Severe alcoholic hepatitis has very high short term mortality and corticosteroids have been the mainstay of treatment for decades. Patients with Lille score >0.45 are considered non-responders to steroids and have poor outcome.
Ravi Daswani, Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal, Anil Arora   +5 more
doaj   +1 more source

Trends in Alcoholic Hepatitis-related Hospitalizations, Financial Burden, and Mortality in the United States

, 2015
BACKGROUND: Alcoholic hepatitis (AH) is the most florid manifestation of alcoholic liver disease which accounts for significant morbidity, mortality, and financial burden.
Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium, Jinjuvadia, Raxitkumar, Liangpunsakul, Suthat   +2 more
core   +1 more source