Results 171 to 180 of about 54,603 (242)

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

open access: yesSmall, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai   +5 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

open access: yesSmall Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles(LNPs)and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu   +6 more
wiley   +1 more source

Acute-on-Chronic Liver Failure: Steps Towards Consensus. [PDF]

open access: yesDiagnostics (Basel)
Goran LG   +2 more
europepmc   +1 more source

Lipid Microparticle‐Based Phantoms Modeling Hepatic Steatosis for the Validation of Quantitative Imaging Techniques

open access: yesSmall Methods, EarlyView.
This paper presents a novel method for creating ultrasound phantoms that accurately replicate fat vesicle sizes encountered in Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD). This approach can improve the understanding of liver fat measurement by creating ultrasound phantoms that link different quantitative imaging techniques to ...
Connor Endsley   +11 more
wiley   +1 more source

A New Classification System for Fatty Liver—What Sonographers Should Know

open access: yesSonography, EarlyView.
ABSTRACT Hepatic steatosis or fatty liver disease is a rapidly emerging health issue and is closely linked to an increase in cardiometabolic conditions such as obesity and type 2 diabetes. The nomenclature surrounding fatty liver has recently undergone multiple reviews to better reflect its underlying causes.
Elspeth L. Keys   +4 more
wiley   +1 more source

Multiple Concomitant Precipitating Factors of Hepatic Encephalopathy Are Associated With a Poor Prognosis in Patients With Cirrhosis Admitted to Intensive Care Unit

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Introduction Management of hepatic encephalopathy relies on the identification and control of precipitating factors (PF). The prognostic value of a PF is unknown, which we aimed to explore. Patients and Methods Single‐center retrospective study of cirrhotic patients included in a prospective cohort admitted to an intensive care unit (ICU ...
Marika Rudler   +7 more
wiley   +1 more source

CiThroModel Improves Prediction of Symptomatic Venous Thromboembolism in Hospitalized Patients With Cirrhosis Without Hepatocellular Carcinoma

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Background & Aims Venous thromboembolism (VTE) is a recognized complication of acutely ill patients, but its incidence and risk factors in those with cirrhosis are uncertain. Methods We retrospectively studied a consecutive cohort of cirrhosis patients non‐electively admitted to our medical unit to determine the rates of symptomatic VTE during
Alberto Zanetto   +10 more
wiley   +1 more source

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