Results 71 to 80 of about 415,200 (261)

Antinuclear antibodies (ANA) in chronic hepatitis C virus infection: correlates of positivity and clinical relevance.

, 2004
We examined correlates of antinuclear antibody (ANA) positivity (ANA+) in individuals with chronic hepatitis C virus (HCV) infection and the effect of positivity on clinical outcome of HCV. Pretreatment sera from 645 patients from three centres in Sweden
Marshall, S, Goldin, RD, A. Alberti, A. J. Hall, Yee, LJ, Thomas, HC, Thursz, MR, Chiaramonte, M, Braconier, J-H, Hall, AJ, L. J. Yee, H. C. Thomas, Braconier, Jean Henrik, R. D. Goldin, M. Chiaramonte, M. R. Thursz, S. Marshall, Kelleher, P, Braconier, Jean Henrik,, Alberti, A, Lund University., J.‐H. Braconier, P. Kelleher   +22 more
core   +1 more source

Elevated endotoxin levels in non-alcoholic fatty liver disease [PDF]

, 2010
Background: Emerging data indicate that gut-derived endotoxin may contribute to low-grade systemic inflammation in insulin resistant states. This study aimed to examine the importance of serum endotoxin and inflammatory markers in non-alcoholic fatty ...
Ashour, E., Steven J Creely, Youssef-Elabd, E., Youssef-Elabd, Elham M., Harte, A., Abdalla, M., Creely, S., Ashour Esmat, da Silva, Nancy F., McTernan Philip G, Mohga S Abdalla, Day, C.P., Day, Christopher Paul, Billyard, T., Burt, Alastair D., Burt Alastair D, Philip G McTernan, Kumar, S., Elham M Youssef-Elabd, da Silva, N.F., Alison L Harte, Burt, A.D., Nancy F da Silva, Amin, Ashraf I., Tripathi, Gyanendra, Sharada, H., Burt, A., McTernan, P. G., Billyard, Thomas, da Silva, N., Harte, A.L., Day Christopher P, Youssef-Elabd Elham M, Tripathi Gyanendra, Alastair D Burt, Sharada, Hayat M., Hayat M Sharada, Kumar Sudhesh, Abdalla Mohga S, Sharada, H.M., Day, C., Abdalla, Mohga S., Sudhesh Kumar, Creely, S.J., McGee Kirsty C, Esmat Ashour, McTernan, P., Abdalla, M.S., Tripathi, G., McGee, K.C., Youssef-Elabd, E.M., Kirsty C McGee, Christopher P Day, Ashour, Esmat, McGee, K., Billyard Thomas, Gyanendra Tripathi, Thomas Billyard, Kumar, Sudhesh, Amin Ashraf I, Amin, A., da Silva Nancy F, Harte, A. L., Ashraf I Amin, McTernan, P.G., Creely, Steven J., McGee, K. C., Harte Alison L, Creely Steven J, Sharada Hayat M, Amin, A.I.   +70 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Morphometric study of hepatic ultrastructure in alcoholic hepatitis [PDF]

, 1987
We undertook a morphometric analysis of hepatocellular organelles in an attempt to correlate their changes with the clinical stages of patients.with alcoholic hepatitis.
Rabin, L., Mendenhall, C.L., Veterans Administration Cooperative Study Group on Alcoholic Hepatitis, Marquet, G., Murphy, D.P., Chedid, A., Chen, T.S.   +6 more
core  

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients

Gut Microbes, 2020
Background and Aims Alcoholic hepatitis is the most severe form of alcohol-related liver disease. While the gut microbiome is known to play a role in disease development and progression, less is known about specific compositional changes of the gut ...
Sonja Lang, Bradley Fairfied, Bei Gao, Yi Duan, Xinlian Zhang, Derrick E. Fouts, Bernd Schnabl   +6 more
doaj   +1 more source

Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options

Cell Adhesion & Migration, 2023
Hepatocellular carcinoma (HCC) is the seventh most highly prevalent malignant tumor globally and the second most common cause of mortality. HCC develops with complex pathways that occur through multistage biological processes.
Sugan Panneerselvam, Cornelia Wilson, Prem Kumar, Dinu Abirami, Jayakrishna Pamarthi, Mettu Srinivas Reddy, Joy Varghese   +6 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases

Canadian Journal of Gastroenterology, 1995
Corticosteroid therapy for acute alcoholic hepatitis has been demonstrated to enhance survival in patients who are encephalopathic, and who do not have renal failure or gastrointestinal bleeding.
Vitor Arantes, Pina Michieletti, Ross Cameron, Jenny Heathcote, Morris Sherman   +4 more
doaj   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source