Results 61 to 70 of about 365,692 (312)

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma [PDF]

Laboratory Investigation, 2010
Hedgehog (Hh) pathway activation promotes many processes that occur during fibrogenic liver repair. Whether the Hh pathway modulates the outcomes of virally mediated liver injury has never been examined. Gene-profiling studies of human hepatocellular carcinomas (HCCs) demonstrate Hh pathway activation in HCCs related to chronic infection with hepatitis
Pereira, Tde A, Witek, RP, Syn, WK, Choi, SS, Bradrick, S, Karaca, GF, Agboola, KM, Jung, Y, Omenetti, A, Moylan, CA, Yang, L, Fernandez-Zapico, ME, Jhaveri, R, Shah, VH, Pereira, FE, Diehl, AM   +15 more
openaire   +2 more sources

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Features of the course of viral hepatitis A in a child with persistent mixed herpesvirus infection

Лечащий Врач
Background. Today in the structure of viral hepatitis viral hepatitis A takes the lead position, the course of typical forms is usually favorable. Over the last few years, however, the frequency of viral hepatitis A has become higher, with increased ...
E. G. Khramtsova, M. D. Subbotina
doaj   +1 more source

A review on hepatitis D: From virology to new therapies

Journal of Advanced Research, 2019
Hepatitis delta virus (HDV) is a defective virus that requires the hepatitis B virus (HBV) to complete its life cycle in human hepatocytes. HDV virions contain an envelope incorporating HBV surface antigen protein and a ribonucleoprotein containing the ...
Nathalie Mentha, Sophie Clément, Francesco Negro, Dulce Alfaiate   +3 more
doaj   +1 more source

Humanized mouse models for human viral hepatitis and related liver diseases [PDF]

Chinese Science Bulletin, 2019
Liver diseases, such as viral hepatitis and related fibrosis, cirrhosis and hepatocellular carcinomas, greatly threaten the health of human beings and constitute a global health problem. Nevertheless, suitable animal models of human liver diseases, especially for hepatitis virus infections, are not yet successfully established to avoid the defects of ...
Xiaonan Ren, Xiaohui Zhou
openaire   +1 more source

Seroprevalence Of Hepatitis-b Virus In Mid And Far Western Region In Nepal [PDF]

, 2012
Hepatitis B is significant health problems that might involve the late sequel of liver cirrhosis and hepatocellular carcinoma. The present study aimed to know the seroprevalence of hepatitis B virus (HBV) in mid and far western region in Nepal with ...
H, S. A. (Siddiqui), M, A. (Ansari), P, S. (Singh), S, K. (Khan)   +3 more
core  

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source