Results 121 to 130 of about 1,633,527 (428)

Integrating Viral Hepatitis Screening and Prevention Services into an Urban Chemical Dependency Treatment Facility for American Indians and Alaska Natives

, 2012
American Indian/Alaska Natives (AI/AN) patients at an urban residential chemical dependency treatment center participated in a viral hepatitis prevention project.
Brucker, Rachel, Buffington, Joanna, Castor, Mei L., Forquera, Ralph, Huffman, Shelly, Redd, John T., Taualii, Maile, Tetrick, Crystal C., Town, Cecile M.   +8 more
core  

Global Distribution and Prevalence of Hepatitis C Virus Genotypes

Hepatology, 2014
Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global ...
J. Messina, I. Humphreys, A. Flaxman, A. Brown, G. Cooke, O. Pybus, E. Barnes   +6 more
semanticscholar   +1 more source

The Antiviral Efficacy and Safety of Azvudine in Hospitalized SARS‐CoV‐2 Infected Patients with Liver Diseases Based on a Multicenter, Retrospective Cohort Study

Advanced Science, EarlyView.
Azvudine shows benefits in reducing all‐cause mortality in hospitalized SARS‐CoV‐2 infected patients and liver diseases. COVID‐19 patients with kidney disease and without autoimmune diseases show a preference for azvudine. Azvudine may be a promising antiviral agent for treating COVID‐19 concomitant with liver diseases.
Junyi Sun, Mengzhao Yang, Guanyue Su, Ling Wang, Xiaobo Hu, Yongjian Zhou, Guangying Cui, Guowu Qian, Yiqiang Yuan, Xinjun Hu, Silin Li, Hong Luo, Shixi Zhang, Guangming Li, Donghua Zhang, Guotao Li, Ming Cheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis

BMC Cancer, 2019
Background Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with discrepant conclusions reached.
Shan Tang, Jing Zhang, Ting-Ting Mei, Hai-Qing Guo, Xin-Huan Wei, Wen-Yan Zhang, Ya-Li Liu, Shan Liang, Zuo-Peng Fan, Li-Xia Ma, Wei Lin, Yi-Rong Liu, Li-Xia Qiu, Hai-Bin Yu   +13 more
doaj   +1 more source

Sofosbuvir for previously untreated chronic hepatitis C infection.

New England Journal of Medicine, 2013
BACKGROUND In phase 2 trials, the nucleotide polymerase inhibitor sofosbuvir was effective in previously untreated patients with chronic hepatitis C virus (HCV) genotype 1, 2, or 3 infection.
E. Lawitz, A. Mangia, D. Wyles, M. Rodríguez-Torres, T. Hassanein, S. Gordon, M. Schultz, Mitchell N. Davis, Z. Kayali, K. Reddy, I. Jacobson, K. Kowdley, L. Nyberg, G. Subramanian, R. Hyland, S. Arterburn, D. Jiang, J. McNally, D. Brainard, W. Symonds, J. Mchutchison, A. Sheikh, Z. Younossi, E. Gane   +23 more
semanticscholar   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Recommendation for Routine Prenatal Screening for Hepatitis C [PDF]

, 2018
Hepatitis C prevalence and incidence are on the rise, both nationally and in Vermont. This project aims to assess the feasibility and potential benefit of implementing routine prenatal Hepatitis C screening, as opposed to screening only patients who fall
Morrison, Althea L
core   +1 more source

Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]

, 2003
Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Folwaczny, Christian, Glas, J., Konig, A., Martin, K., Schaefer, M., Schiemann, Uwe, Schmidt, F., Simperl, C., Torok, P.   +8 more
core   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Hepatitis Viral Akut E.c Hepatitis Virus a Pada Anak [PDF]

, 2014
Latar Belakang. Hepatitis A merupakan penyakit infeksi sistemik yang dominan menyerang hati, disebabkan oleh infeksi virus Hepatitis A (HAV). Infeksi HAV terjadi di seluruh dunia terutama masih endemis di negara berkembang, karena keadaan lingkungan ...
Syah, S. M. (Sutan)
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