Results 181 to 190 of about 1,633,527 (428)

A hepatitis C virus (HCV) fertőzés pathogenesise: a genetikai és az immunológiai tényezők, valamint az oxidativ stress szerepe és a kórokozó virus sajátosságai, különös tekintettel a HCV-okozta betegségekben és a tünetmentes virushordozó állapotban = Pathogenesis of hepatitis C virus (HCV) infection: the role of the genetic and immunological factors, the oxidative stress and the viral features in the HCV-related diseases and in the symptomfree virus carriers [PDF]

open access: yes, 2009
Genetikai, immunológiai és környezeti tényezők potenciális szerepe krónikus hepatitis C virus (HCV) infekcióban: összehasonlitó vizsgálatok aktiv HCV hepatitises betegekben és tünetmentes "egészséges" virushordozókban. 1.
Berki, Timea   +5 more
core  

STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS [PDF]

open access: green, 1952
Miles E. Drake   +6 more
openalex   +1 more source

Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang   +16 more
wiley   +1 more source

Cloning and expression of hepatitis E virus ORF2 as an immunogen protein in baculovirus expression system

open access: yesVaccine Research, 2018
Introduction: Hepatitis E virus (HEV) is a non-enveloped, single-stranded positive-sense RNA virus. It is one of the most important causes of liver failures and the mortality rate arising from HEV is more common in pregnant women.
SA Sadeghi   +6 more
doaj  

The Interleukin-6 gene variants may protect against SARS-CoV-2 infection and the severity of COVID-19: a case-control study in a Moroccan population

open access: yesBMC Medical Genomics
The symptoms of SARS-CoV-2 infection vary widely, ranging from asymptomatic cases to severe forms marked by acute respiratory distress syndrome, multi-organ damage, and fatalities.
Rachid Noureddine   +11 more
doaj   +1 more source

Hepatic vessel segmentation using a reduced filter 3D U-Net in ultrasound imaging [PDF]

open access: yesarXiv, 2019
Accurate hepatic vessel segmentation on ultrasound (US) images can be an important tool in the planning and execution of surgery, however proves to be a challenging task due to noise and speckle. Our method comprises a reduced filter 3D U-Net implementation to automatically detect hepatic vasculature in 3D US volumes.
arxiv  

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

open access: yesAdvanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian   +5 more
wiley   +1 more source

PDCD11 Stabilizes C‐MYC Oncoprotein by Hindering C‐MYC‐SKP2 Negative Feedback Loop to Facilitate Progression of p53‐Mutant Breast and Colon Malignancies

open access: yesAdvanced Science, EarlyView.
PDCD11 overexpression highly correlates to poor prognosis in p53‐mutant breast and colon cancers. Through interaction with C‐MYC in the nucleoplasm, PDCD11 hinders C‐MYC‐induced SKP2 from binding to the C‐MYC MB2 domain for ubiquitination, thereby stabilizing C‐MYC to drive tumor progression.
Li Ding   +12 more
wiley   +1 more source

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